Low‐level increases in serum C‐reactive protein are present in early osteoarthritis of the knee and predict progressive disease

Low‐level increases in serum C‐reactive protein are present in early osteoarthritis of the... Objective. To examine the role of low‐grade inflammation in the etiology and progression of early osteoarthritis (OA) of the knee. Methods. We used a new, high‐sensitivity, automated monoclonal antibody immunoassay for the classic acute‐phase protein, C‐reactive protein (CRP), in serum. Anteroposterior radiographs of the knee with weight bearing were obtained on 845 women (ages 44–67) on entry into a population‐based study of OA in Chingford, North London. In those defined radiologically as “cases,” the knee radiographs were repeated after 4 years. Results. Levels of CRP were higher in 105 women with knee OA defined radiologically as Kellgren‐Lawrence grade 2+ (median 2.4 mg/liter, interquartile range (IQR) 1.0–5.1), compared with 740 women without OA (median 0.7 mg/liter, IQR 0.3–1.8) (P < 0.001). Median levels of CRP were higher in the 31 women whose disease progressed at least 1 Kellgren‐Lawrence grade (median 2.6 mg/liter, IQR 1.9–4.6), compared with the 39 whose disease did not (median 1.3 mg/liter, IQR 0.6–2.4) (P = 0.006). The significance of these differences persisted after adjustment for age, weight, height, smoking, knee pain, or injury. Classifying disease by the presence of joint space narrowing or osteophytes alone produced similar results. Conclusion. CRP levels are modestly but significantly increased in women with early knee OA, and higher levels predict those whose disease will progress over 4 years, suggesting that low‐grade inflammation may be a significant aspect of early OA and may be amenable to therapeutic intervention and secondary prevention. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatology Wiley

Low‐level increases in serum C‐reactive protein are present in early osteoarthritis of the knee and predict progressive disease

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Publisher
Wiley
Copyright
Copyright © 1997 American College of Rheumatology
ISSN
0004-3591
eISSN
1529-0131
D.O.I.
10.1002/art.1780400419
Publisher site
See Article on Publisher Site

Abstract

Objective. To examine the role of low‐grade inflammation in the etiology and progression of early osteoarthritis (OA) of the knee. Methods. We used a new, high‐sensitivity, automated monoclonal antibody immunoassay for the classic acute‐phase protein, C‐reactive protein (CRP), in serum. Anteroposterior radiographs of the knee with weight bearing were obtained on 845 women (ages 44–67) on entry into a population‐based study of OA in Chingford, North London. In those defined radiologically as “cases,” the knee radiographs were repeated after 4 years. Results. Levels of CRP were higher in 105 women with knee OA defined radiologically as Kellgren‐Lawrence grade 2+ (median 2.4 mg/liter, interquartile range (IQR) 1.0–5.1), compared with 740 women without OA (median 0.7 mg/liter, IQR 0.3–1.8) (P < 0.001). Median levels of CRP were higher in the 31 women whose disease progressed at least 1 Kellgren‐Lawrence grade (median 2.6 mg/liter, IQR 1.9–4.6), compared with the 39 whose disease did not (median 1.3 mg/liter, IQR 0.6–2.4) (P = 0.006). The significance of these differences persisted after adjustment for age, weight, height, smoking, knee pain, or injury. Classifying disease by the presence of joint space narrowing or osteophytes alone produced similar results. Conclusion. CRP levels are modestly but significantly increased in women with early knee OA, and higher levels predict those whose disease will progress over 4 years, suggesting that low‐grade inflammation may be a significant aspect of early OA and may be amenable to therapeutic intervention and secondary prevention.

Journal

Arthritis & RheumatologyWiley

Published: Apr 1, 1997

References

  • The relative toxicity of nonsteroidal antiinflammatory drugs
    Fries, Fries; Williams, Williams; Bloch, Bloch
  • Acute‐phase proteins in osteoarthritis
    Sipe, Sipe
  • Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee
    Sharif, Sharif; George, George; Shepstone, Shepstone; Knudson, Knudson; Thonar, Thonar; Cushnoghan, Cushnoghan; Dieppe, Dieppe

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