Low‐Dose Effect of Ethanol on Locomotor Activity Induced by Activation of the Mesolimbic System

Low‐Dose Effect of Ethanol on Locomotor Activity Induced by Activation of the Mesolimbic System Four experiments were designed to study the ability of 0.5 g/kg ethanol (EtOH) intraperitoneally to modify locomotor activity induced by drugs that interact with different sites in the mesolimbic system (MLS) of male Sprague‐Dawley rats. Locomotor activity was measured in a doughnut‐shaped circular arena after various treatments. EtOH alone did not alter locomotor activity in any of the experiments. Amphetamine (AMP, intraperitoneally or intraaccumbens) increased locomotor activity in a dose‐dependent manner, and the presence of EtOH attenuated AMP‐induced locomotor activity. Bilateral infusion of GABAA antagonist picrotoxin (PIC) into the ventral tegmental area also increased locomotor activity in a dose‐dependent manner, and the presence of EtOH attenuated PIC‐induced locomotor activity. On the other hand, the interaction between bilateral infusion of μ‐receptor agonist Tyr‐D‐Ala‐Gly‐NMe‐Phe‐Gly‐ol (DAGO) and EtOH on locomotor activity is complex. The highest dose of DAGO that significantly increased locomotor activity was not affected by the presence of EtOH. But, with lower doses of DAGO that either had no effect or a small increase in locomotor activity, the combination of EtOH and DAGO increased and attenuated locomotor activity, respectively. Results from this study support our hypothesis that a low dose of EtOH that does not modify behavior can interact with neurotransmitter systems in the brain and modify drug‐induced locomotor activity. Modification of this drug‐induced locomotor activity by a low dose of EtOH is dependent on the rate of ongoing locomotor behavior induced by drug and the neurotransmitter substrate that the drug modified to induce locomotor behavior. Based on the results, we speculate that a low dose of EtOH probably interacts with dopaminergic and GABAergic neurotransmitter systems and not with opiopeptidergic systems in the MLS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcoholism: Clinical & Experimental Research Wiley

Low‐Dose Effect of Ethanol on Locomotor Activity Induced by Activation of the Mesolimbic System

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Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0145-6008
eISSN
1530-0277
DOI
10.1111/j.1530-0277.1995.tb01581.x
Publisher site
See Article on Publisher Site

Abstract

Four experiments were designed to study the ability of 0.5 g/kg ethanol (EtOH) intraperitoneally to modify locomotor activity induced by drugs that interact with different sites in the mesolimbic system (MLS) of male Sprague‐Dawley rats. Locomotor activity was measured in a doughnut‐shaped circular arena after various treatments. EtOH alone did not alter locomotor activity in any of the experiments. Amphetamine (AMP, intraperitoneally or intraaccumbens) increased locomotor activity in a dose‐dependent manner, and the presence of EtOH attenuated AMP‐induced locomotor activity. Bilateral infusion of GABAA antagonist picrotoxin (PIC) into the ventral tegmental area also increased locomotor activity in a dose‐dependent manner, and the presence of EtOH attenuated PIC‐induced locomotor activity. On the other hand, the interaction between bilateral infusion of μ‐receptor agonist Tyr‐D‐Ala‐Gly‐NMe‐Phe‐Gly‐ol (DAGO) and EtOH on locomotor activity is complex. The highest dose of DAGO that significantly increased locomotor activity was not affected by the presence of EtOH. But, with lower doses of DAGO that either had no effect or a small increase in locomotor activity, the combination of EtOH and DAGO increased and attenuated locomotor activity, respectively. Results from this study support our hypothesis that a low dose of EtOH that does not modify behavior can interact with neurotransmitter systems in the brain and modify drug‐induced locomotor activity. Modification of this drug‐induced locomotor activity by a low dose of EtOH is dependent on the rate of ongoing locomotor behavior induced by drug and the neurotransmitter substrate that the drug modified to induce locomotor behavior. Based on the results, we speculate that a low dose of EtOH probably interacts with dopaminergic and GABAergic neurotransmitter systems and not with opiopeptidergic systems in the MLS.

Journal

Alcoholism: Clinical & Experimental ResearchWiley

Published: Jun 1, 1995

Keywords: ; ; ;

References

  • An animal model for low dose ethanol‐induced locomotor stimulation. Behavioral characteristics
    Erickson, CK; Kochhar, A
  • An evaluation of the locomotor stimulating action of ethanol in rats and mice
    Frye, GD; Breese, GR
  • Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area
    Kalivas, PW; Richardson‐Carlson, R
  • The effect of ethanol on wheel running in rats
    Duncan, PM; Baez, AM
  • Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine
    Perugini, M; Vezina, P
  • Interaction of the effects and the metabolism of d‐amphetamine by ethanol
    Todzy, I; Becker, W
  • Ethanol‐amphetamine interaction effects on spontaneous motor activity and fixed‐interval responding
    Duncan, PM; Cook, NJ

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