Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of... Transforming growth factor‐β (TGF‐β), interleukin‐10 (IL‐10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the association between body mass index (BMI), hemoglobin, total protein, albumin, globulin (GLB), albumin/GLB ratio (AGR), pre‐albumin, prognostic nutritional index, and TGF‐β, IL‐10, and Foxp3 mRNA expression in patients with breast cancer. Quantitative real‐time PCR was used to detect the mRNA expression of TGF‐β, IL‐10, and Foxp3 in the peripheral blood of 107 patients with breast cancer and 21 healthy controls. We found that TGF‐β mRNA levels were 2.6‐fold, 3.2‐fold, and 2.3‐fold higher in patients with low BMI (<23), low AGR, and high GLB, respectively, than in their counterparts (P < 0.05). In addition, IL‐10 mRNA expression levels in patients with normal BMI (<23) were 2.8‐fold and 3.5‐fold higher than in those who were overweight (23≤ BMI <25) and obese (BMI ≥ 25), respectively (P < 0.05). In addition, TGF‐β, IL‐10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer. © 2018 IUBMB Life, 70(3):237–245, 2018 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
D.O.I.
10.1002/iub.1721
Publisher site
See Article on Publisher Site

Abstract

Transforming growth factor‐β (TGF‐β), interleukin‐10 (IL‐10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the association between body mass index (BMI), hemoglobin, total protein, albumin, globulin (GLB), albumin/GLB ratio (AGR), pre‐albumin, prognostic nutritional index, and TGF‐β, IL‐10, and Foxp3 mRNA expression in patients with breast cancer. Quantitative real‐time PCR was used to detect the mRNA expression of TGF‐β, IL‐10, and Foxp3 in the peripheral blood of 107 patients with breast cancer and 21 healthy controls. We found that TGF‐β mRNA levels were 2.6‐fold, 3.2‐fold, and 2.3‐fold higher in patients with low BMI (<23), low AGR, and high GLB, respectively, than in their counterparts (P < 0.05). In addition, IL‐10 mRNA expression levels in patients with normal BMI (<23) were 2.8‐fold and 3.5‐fold higher than in those who were overweight (23≤ BMI <25) and obese (BMI ≥ 25), respectively (P < 0.05). In addition, TGF‐β, IL‐10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer. © 2018 IUBMB Life, 70(3):237–245, 2018

Journal

IUBMB LifeWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ;

References

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