IntroductionOn February 19, 2016, the National Institutes of Health (NIH) hosted a workshop on “Loss of Skills and Onset Patterns in Neurodevelopmental Disorders: Understanding the Neurobiological Mechanisms”. Participants discussed the state of the science concerning understanding the variability in onset patterns, particularly the phenomenon of developmental regression, in Autism Spectrum Disorder (ASD) and related disorders. Consideration was given to model systems and cutting‐edge methods that may afford opportunities for a better understanding of the neurobiological pathways that deviate from typical developmental trajectories. Here, we summarize what is known about onset patterns in ASD, based on the discussion during the meeting, and consider the concept of critical periods for specific skills as a potential clue to underlying biology explaining different onset patterns. Research on Rett Syndrome, a rare genetic disorder that includes regression, is presented as a model for translational research. We then discuss tool development and methods that may ultimately be used for a better understanding of the mechanisms underlying onset patterns in neurodevelopmental disorders, leading to identification of biologically distinct subtypes and treatment targets.Loss of Skills and Patterns of Onset in ASDASD is a neurodevelopmental condition with highly diverse clinical expression, reflecting etiological heterogeneity [Geschwind & Levitt, ].
Autism Research – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera
Read and print from thousands of top scholarly journals.
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
ok to continue