Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social‐environmental factors on post‐traumatic stress disorder in Chinese Han adolescents after Wenchuan earthquake

Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social‐environmental... INTRODUCTIONPost‐traumatic stress disorder (PTSD) is an anxiety disorder developed after exposures to severe traumatic events that threaten physical injury or death (Zoladz & Diamond, ). Although pathophysiological mechanism of this disorder has not been elucidate yet, gene‐environment interactions are considered to result in the development of PTSD (Liberzon et al., ; Tian et al., ). Genetic factors contribute approximately 32–35% of the variance of PTSD symptoms (Afifi, Asmundson, Taylor, & Jang, ; Xian et al., ). A number of single nucleotide polymorphisms (SNPs) have been found to be linked to the susceptibility of PTSD (Ryan, Chaudieu, Ancelin, & Saffery, ; Stein et al., ), and some of which may interact with environment to increase the risk of PTSD (Smoller, ; Tian et al., ).Indirect evidences suggest associations of estrogen receptor alpha (ESR1) with PTSD. ESR1 is expressed in hippocampus, amygdala, and medial prefrontal cortex (Osterlund & Hurd, ), indicating its roles in affective, emotional, and motivational behaviors (McEwen, ; Osterlund & Hurd, ; Ostlund, Keller, & Hurd, ; Westberg & Eriksson, ). In addition, PTSD patients had lower hippocampal volume than healthy controls in men and women (Bremner et al., ; Zandieh et al., ), diminished right basolateral amygdala http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social‐environmental factors on post‐traumatic stress disorder in Chinese Han adolescents after Wenchuan earthquake

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1552-4841
eISSN
1552-485X
D.O.I.
10.1002/ajmg.b.32615
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONPost‐traumatic stress disorder (PTSD) is an anxiety disorder developed after exposures to severe traumatic events that threaten physical injury or death (Zoladz & Diamond, ). Although pathophysiological mechanism of this disorder has not been elucidate yet, gene‐environment interactions are considered to result in the development of PTSD (Liberzon et al., ; Tian et al., ). Genetic factors contribute approximately 32–35% of the variance of PTSD symptoms (Afifi, Asmundson, Taylor, & Jang, ; Xian et al., ). A number of single nucleotide polymorphisms (SNPs) have been found to be linked to the susceptibility of PTSD (Ryan, Chaudieu, Ancelin, & Saffery, ; Stein et al., ), and some of which may interact with environment to increase the risk of PTSD (Smoller, ; Tian et al., ).Indirect evidences suggest associations of estrogen receptor alpha (ESR1) with PTSD. ESR1 is expressed in hippocampus, amygdala, and medial prefrontal cortex (Osterlund & Hurd, ), indicating its roles in affective, emotional, and motivational behaviors (McEwen, ; Osterlund & Hurd, ; Ostlund, Keller, & Hurd, ; Westberg & Eriksson, ). In addition, PTSD patients had lower hippocampal volume than healthy controls in men and women (Bremner et al., ; Zandieh et al., ), diminished right basolateral amygdala

Journal

American Journal of Medical GeneticsWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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