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Long‐term persistence of hepatocarcinogenic potential of a non‐hypervascular hypointense nodule on EOB‐MRI after the eradication of hepatitis C virus

Long‐term persistence of hepatocarcinogenic potential of a non‐hypervascular hypointense nodule... Non‐hypervascular hypointense nodules (NHHNs) on gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid–enhanced magnetic resonance imaging (EOB‐MRI) have a high likelihood of hypervascularization progressing to typical hypervascular hepatocellular carcinoma (HCC). NHHNs that were present before the start of anti‐hepatitis C virus (HCV) therapy is a risk marker for HCC development after achieving sustained virologic response (SVR). In this report, we show a patient without a previous history of HCC in whom HCC developed by hypervascularization of NHHN after SVR. This patient achieved SVR more than 8 years before NHHN developed into HCC, and during this time NHHN had been present but had remained unchanged in size and imaging features as shown by repeated EOB‐MRI. Hepatocarcinogenic potential of NHHNs persist for a long time after SVR, despite the eradication of HCV. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hepatology Research Wiley

Long‐term persistence of hepatocarcinogenic potential of a non‐hypervascular hypointense nodule on EOB‐MRI after the eradication of hepatitis C virus

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References (13)

Publisher
Wiley
Copyright
© 2021 The Japan Society of Hepatology.
ISSN
1386-6346
eISSN
1872-034X
DOI
10.1111/hepr.13707
Publisher site
See Article on Publisher Site

Abstract

Non‐hypervascular hypointense nodules (NHHNs) on gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid–enhanced magnetic resonance imaging (EOB‐MRI) have a high likelihood of hypervascularization progressing to typical hypervascular hepatocellular carcinoma (HCC). NHHNs that were present before the start of anti‐hepatitis C virus (HCV) therapy is a risk marker for HCC development after achieving sustained virologic response (SVR). In this report, we show a patient without a previous history of HCC in whom HCC developed by hypervascularization of NHHN after SVR. This patient achieved SVR more than 8 years before NHHN developed into HCC, and during this time NHHN had been present but had remained unchanged in size and imaging features as shown by repeated EOB‐MRI. Hepatocarcinogenic potential of NHHNs persist for a long time after SVR, despite the eradication of HCV.

Journal

Hepatology Research – Wiley

Published: Jan 1, 2022

Keywords: EOB‐MRI; hepatocarcinogenesis; non‐hypervascular hypointense nodule; SVR

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