Lipophilicity evaluation of some thiazolyl‐1,3,4‐oxadiazole derivatives with antifungal activity

Lipophilicity evaluation of some thiazolyl‐1,3,4‐oxadiazole derivatives with antifungal activity The chromatographic behavior of a series of thiazolyl‐1,3,4‐oxadiazoles with antifungal activity was studied by reverse‐phase thin‐layer chromatography (RP‐TLC). The lipophilicity parameters derived from RP‐TLC were correlated with the data derived from liquid‐chromatography mass‐spectrometry. Good linear relationships were observed between the chromatographic lipophilicity parameters and the theoretical lipophilicity descriptors (logP) generated by various computer software and internet modules. Principal component analysis, applied on the experimental chromatographic lipophilicity indices and the theoretically calculated logP, enabled us to obtain a lipophilicity chart for better vizualization of the similarities and differences of the investigated compounds, which were grouped by k‐means clustering in two congeneric classes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomedical Chromatography Wiley

Lipophilicity evaluation of some thiazolyl‐1,3,4‐oxadiazole derivatives with antifungal activity

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Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons, Ltd.
ISSN
0269-3879
eISSN
1099-0801
D.O.I.
10.1002/bmc.4221
Publisher site
See Article on Publisher Site

Abstract

The chromatographic behavior of a series of thiazolyl‐1,3,4‐oxadiazoles with antifungal activity was studied by reverse‐phase thin‐layer chromatography (RP‐TLC). The lipophilicity parameters derived from RP‐TLC were correlated with the data derived from liquid‐chromatography mass‐spectrometry. Good linear relationships were observed between the chromatographic lipophilicity parameters and the theoretical lipophilicity descriptors (logP) generated by various computer software and internet modules. Principal component analysis, applied on the experimental chromatographic lipophilicity indices and the theoretically calculated logP, enabled us to obtain a lipophilicity chart for better vizualization of the similarities and differences of the investigated compounds, which were grouped by k‐means clustering in two congeneric classes.

Journal

Biomedical ChromatographyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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