Linkage studies of enzyme markers in man‐mouse somatic cell hybrids

Linkage studies of enzyme markers in man‐mouse somatic cell hybrids Linkage studies of enzyme markers in man-mouse somatic cell hybrids BY CLAUDE BILLARDON, NGUYEN VAN CONG, JEAN-YVES PICARD, CHARLES LE BORGNE DE KAOmL, RBGIS REBOURCET, DOMINIQUE WEIL, JOSU.@FEINGOLD AND JEAN FRBZAL Clinique et Unitd de Recherchea de Qdndtique Mddicale (I.N.KE.R.M.), u Hbital h Enfants Malades, 149 r e de 5&vres,Paris 16&me, France Hybridization between man and mouse somatic cells provides a new and promising technique for genetic linkage analysis in man because the man-mouse hybrid cell preferentially undergoes human chromosome elimination (Barski, Sorieul & Cornefert, 1960, 1961; Ephrussi & Sorieul, 1962; Weiss & Green, 1967). Some results reported here have been published in preliminary ) notes (Nguyen Van Cong et al. 1 9 7 1 ~b ; Billardon et al. 1971; Picard et al. 1971; Fellow et al. 1971). Similar data have been reported by other workers (Santachiara et d. 1970; Ruddle et al. 1970; Westerveld et al. 1971 ;Meera Khan et d.1971; Puck et al. 1971 ;Shows, 1972). Our purpose in this report is to discuss our data obtained with enzyme markers and to examine the possible interpretations. MATERIALS AND METHODS Origin of the parental cells A number of different cell lines were used to perform the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

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Publisher
Wiley
Copyright
Copyright © 1973 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1973.tb00590.x
Publisher site
See Article on Publisher Site

Abstract

Linkage studies of enzyme markers in man-mouse somatic cell hybrids BY CLAUDE BILLARDON, NGUYEN VAN CONG, JEAN-YVES PICARD, CHARLES LE BORGNE DE KAOmL, RBGIS REBOURCET, DOMINIQUE WEIL, JOSU.@FEINGOLD AND JEAN FRBZAL Clinique et Unitd de Recherchea de Qdndtique Mddicale (I.N.KE.R.M.), u Hbital h Enfants Malades, 149 r e de 5&vres,Paris 16&me, France Hybridization between man and mouse somatic cells provides a new and promising technique for genetic linkage analysis in man because the man-mouse hybrid cell preferentially undergoes human chromosome elimination (Barski, Sorieul & Cornefert, 1960, 1961; Ephrussi & Sorieul, 1962; Weiss & Green, 1967). Some results reported here have been published in preliminary ) notes (Nguyen Van Cong et al. 1 9 7 1 ~b ; Billardon et al. 1971; Picard et al. 1971; Fellow et al. 1971). Similar data have been reported by other workers (Santachiara et d. 1970; Ruddle et al. 1970; Westerveld et al. 1971 ;Meera Khan et d.1971; Puck et al. 1971 ;Shows, 1972). Our purpose in this report is to discuss our data obtained with enzyme markers and to examine the possible interpretations. MATERIALS AND METHODS Origin of the parental cells A number of different cell lines were used to perform the

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1973

References

  • Inherited variations in human phosphohexose isomerase.
    Detter, Detter; Ways, Ways; Giblett, Giblett; Baughan, Baughan; Hopkinson, Hopkinson; Povey, Povey; Harris, Harris
  • Inherited variants of human nucleoside phosphorylase.
    Edwards, Edwards; Hopkinson, Hopkinson; Harris, Harris
  • Human red cell peptidases.
    Lewis, Lewis; Harris, Harris
  • Data on the incidence, segregation and linkage relations of the adenylate kinase (AK) polymorphism.
    Rapley, Rapley; Robinson, Robinson; Harris, Harris; Maynard‐Smith, Maynard‐Smith

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