Linkage studies of enzyme markers in man-mouse somatic cell hybrids BY CLAUDE BILLARDON, NGUYEN VAN CONG, JEAN-YVES PICARD, CHARLES LE BORGNE DE KAOmL, RBGIS REBOURCET, DOMINIQUE WEIL, JOSU.@FEINGOLD AND JEAN FRBZAL Clinique et Unitd de Recherchea de Qdndtique Mddicale (I.N.KE.R.M.), u Hbital h Enfants Malades, 149 r e de 5&vres,Paris 16&me, France Hybridization between man and mouse somatic cells provides a new and promising technique for genetic linkage analysis in man because the man-mouse hybrid cell preferentially undergoes human chromosome elimination (Barski, Sorieul & Cornefert, 1960, 1961; Ephrussi & Sorieul, 1962; Weiss & Green, 1967). Some results reported here have been published in preliminary ) notes (Nguyen Van Cong et al. 1 9 7 1 ~b ; Billardon et al. 1971; Picard et al. 1971; Fellow et al. 1971). Similar data have been reported by other workers (Santachiara et d. 1970; Ruddle et al. 1970; Westerveld et al. 1971 ;Meera Khan et d.1971; Puck et al. 1971 ;Shows, 1972). Our purpose in this report is to discuss our data obtained with enzyme markers and to examine the possible interpretations. MATERIALS AND METHODS Origin of the parental cells A number of different cell lines were used to perform the
Annals of Human Genetics – Wiley
Published: Jan 1, 1973
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera