LIGHT DAMAGE IN THE RAT RETINA: EFFECT OF A RADIOPROTECTIVE AGENT (WR‐77913) ON ACUTE ROD OUTER SEGMENT DISK DISRUPTIONS

LIGHT DAMAGE IN THE RAT RETINA: EFFECT OF A RADIOPROTECTIVE AGENT (WR‐77913) ON ACUTE ROD OUTER... Primary events in the course of light induced retinal lesions are still not fully elucidated. Under chronic conditions, lipid peroxidation in the retina and death of photoreceptor cells are observed. The radioprotective agent WR‐77913 scavenges singlet oxygen, hydrated electrons and free radicals. WR‐77913 was used to protect against acute light induced photoreceptor outer segment membrane disruptions in the rat retina. There was a partial but not complete protection at higher illuminance levels (800 lx for 30 min), whereas threshold lesions (400 lx for 30 min) were almost completely prevented. These observations indicate an involvement of photodynamic reactions in causing acute ohotoreceDtor lesions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Photochemistry & Photobiology Wiley

LIGHT DAMAGE IN THE RAT RETINA: EFFECT OF A RADIOPROTECTIVE AGENT (WR‐77913) ON ACUTE ROD OUTER SEGMENT DISK DISRUPTIONS

Loading next page...
 
/lp/wiley/light-damage-in-the-rat-retina-effect-of-a-radioprotective-agent-wr-X97XsuK3d5
Publisher
Wiley
Copyright
Copyright © 1991 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0031-8655
eISSN
1751-1097
D.O.I.
10.1111/j.1751-1097.1991.tb01997.x
Publisher site
See Article on Publisher Site

Abstract

Primary events in the course of light induced retinal lesions are still not fully elucidated. Under chronic conditions, lipid peroxidation in the retina and death of photoreceptor cells are observed. The radioprotective agent WR‐77913 scavenges singlet oxygen, hydrated electrons and free radicals. WR‐77913 was used to protect against acute light induced photoreceptor outer segment membrane disruptions in the rat retina. There was a partial but not complete protection at higher illuminance levels (800 lx for 30 min), whereas threshold lesions (400 lx for 30 min) were almost completely prevented. These observations indicate an involvement of photodynamic reactions in causing acute ohotoreceDtor lesions.

Journal

Photochemistry & PhotobiologyWiley

Published: Jul 1, 1991

References

  • Photodynamic lipid peroxidation in biological systems
    Girotti, Girotti
  • In vitro studies on the photosensitized oxidation of lens proteins by porphyrins
    Roberts, Roberts; Dillon, Dillon
  • In vivo and photophysical studies on photooxidative damage to lens proteins and their protection by radioprotectors
    Roberts, Roberts; Kinley, Kinley; Young, Young; Jenkins, Jenkins; Atherton, Atherton; Dillon, Dillon
  • Intracellular topography of rhodopsin regeneration in vertebrate rods
    Williams, Williams; Penn, Penn

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off