Correspondence Clinical Letter inflammatory infiltrate with numerous eosinophils was noted Clinical Letter in the dermis (Figure 2a). Direct immunofluorescence (DIF) from perilesional skin showed linear IgG and C3 deposits at the dermoepidermal junction (Figure 2b). Enzyme- linked immunosorbent assay (Euroimmun: ELISA) revealed high levels of circulating autoantibodies directed against BP180 DOI: 10.1111/ddg.13434 (109.35 U/mL, positive > 20 U/mL); anti-BP230 autoanti- bodies were not detected. Following clinical, pathological Dear Editors, and immunological correlation, the diagnosis of LPP was established. A 25-year-old man was referred to our department for evalua- The patient was started on prednisolone 0.75 mg/kg/day, tion of disseminated, pruritic papular skin lesions that had which led to rapid improvement within one month (Figure centrifugally spread over the preceding three months. The 1c). Prednisolone was subsequently tapered and discontinued patient reported that tense blisters had appeared on pre-exis- after three months. At one-year follow-up, there was no ting lesions on the forearms one week prior to consultation. evidence of clinical or serological relapse (anti-BP180 He was otherwise healthy and denied drug intake or recent autoantibodies were below the detection threshold). infections. Lichen planus pemphigoides is a rare autoimmune sub- Physical examination revealed shiny, erythemato-viola- epidermal blistering disease characterized by
Journal Der Deutschen Dermatologischen Gesellschaft – Wiley
Published: Jan 1, 2018
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