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/lp/wiley/lf-16-0687-ms-a-bradykinin-b-2-receptor-antagonist-reduces-ischemic-sNF7o3Ik9Z
- Publisher
- Wiley
- Copyright
- 2003 British Pharmacological Society
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- DOI
- 10.1038/sj.bjp.0705385
- pmid
- 12922942
- Publisher site
- See Article on Publisher Site
Abstract
Bradykinin promotes neuronal damage and brain edema through the activation of the B2 receptor. The neuroprotective effect of LF 16‐0687 Ms, a B2 receptor antagonist, has been described when given prior to induction of transient focal cerebral ischemia in rat, but there are no data regarding the consequence of a treatment when given after injury. Therefore, in a murine model of transient middle cerebral artery occlusion (MCAO), we evaluated the effect of LF 16‐0687 Ms given prior to and/or after the onset of ischemia on neurological deficit, infarct volume and inflammatory responses including cerebral edema, blood–brain barrier (BBB) disruption and neutrophil accumulation. LF 16‐0687 Ms (1, 2 and 4 mg kg−1) administered 0.5 h before and, 1.25 and 6 h after MCAO, decreased the infarct volume by a maximum of 33% and significantly improved the neurological recovery. When given at 0.25 and 6.25 h after MCAO, LF 16‐0687 Ms (1.5, 3 and 6 mg kg−1) decreased the infarct volume by a maximum of 25% and improved the neurological score. Post‐treatment with LF 16‐0687 Ms (1.5 mg kg−1) significantly decreased brain edema (−28%), BBB disruption (−60%) and neutrophil accumulation (−65%) induced by ischemia. Physiological parameters were not modified by LF 16‐0687 Ms. These data emphasize the role of bradykinin B2 receptor in the development of infarct lesion, neurological deficit and inflammatory responses resulting from transient focal cerebral ischemia. Therefore, B2 receptor antagonist might represent a new therapeutic approach in the pharmacological treatment of stroke. British Journal of Pharmacology (2003) 139, 1539–1547. doi:10.1038/sj.bjp.0705385
Journal
British Journal of Pharmacology – Wiley
Published: Aug 1, 2003
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References
-
Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verificationBARONE, BARONE; HILLEGASS, HILLEGASS; PRICE, PRICE; WHITE, WHITE; LEE, LEE; FEUERSTEIN, FEUERSTEIN; SARAU, SARAU; CLARK, CLARK; GRISWOLD, GRISWOLD
-
Evaluation of 2,3,5‐triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in ratsBEDERSON, BEDERSON; PITTS, PITTS; GERMANO, GERMANO; NISHIMURA, NISHIMURA; DAVIS, DAVIS; BARTKOWSKI, BARTKOWSKI
-
Kallikrein and kinin receptor expression in inflammation and cancerBHOOLA, BHOOLA; RAMSAROOP, RAMSAROOP; PLENDL, PLENDL; CASSIM, CASSIM; DLAMINI, DLAMINI; NAICKER, NAICKER
-
Translocation of the neutrophil kinin moiety and changes in the regulation of kinin receptors in inflammationBHOOLA, BHOOLA
-
Bioregulation of kinins: kallikreins, kininogens, and kininasesBHOOLA, BHOOLA; FIGUEROA, FIGUEROA; WORTHY, WORTHY
-
Kinins and kinin receptors: importance for the activation of leukocytesBOCKMANN, BOCKMANN; PAEGELOW, PAEGELOW
-
Involvement of bradykinin B1 and B2 receptors in human PMN elastase release and increase in endothelial cell monolayer permeabilityCARL, CARL; MOORE, MOORE; MOORE, MOORE; WHALLEY, WHALLEY
-
Cold‐induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn‐superoxide dismutaseCHAN, CHAN; YANG, YANG; CHEN, CHEN; CARLSON, CARLSON; EPSTEIN, EPSTEIN
-
B2 bradykinin receptor immunoreactivity in rat brainCHEN, CHEN; EMERICH, EMERICH; BARTUS, BARTUS; KORDOWER, KORDOWER
-
A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimersCHERONIS, CHERONIS; WHALLEY, WHALLEY; NGUYEN, NGUYEN; EUBANKS, EUBANKS; ALLEN, ALLEN; DUGGAN, DUGGAN; LOY, LOY; BONHAM, BONHAM; BLODGETT, BLODGETT
-
Beneficial actions of CP‐0127, a novel bradykinin receptor antagonist, in murine traumatic shockCHRISTOPHER, CHRISTOPHER; MA, MA; GAUTHIER, GAUTHIER; LEFER, LEFER
-
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venomCOSTA, COSTA; MORENO, MORENO; ESQUISATTO, ESQUISATTO; JULIANO, JULIANO; BRAIN, BRAIN; NUCCI, NUCCI; ANTUNES, ANTUNES
-
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesiaCUNHA, CUNHA; POOLE, POOLE; LORENZETTI, LORENZETTI; FERREIRA, FERREIRA
-
L‐NAME reduces infarction, neurological deficit and blood–brain barrier disruption following cerebral ischemia in miceDING‐ZHOU, DING‐ZHOU; MARCHAND‐VERRECCHIA, MARCHAND‐VERRECCHIA; CROCI, CROCI; PLOTKINE, PLOTKINE; MARGAILL, MARGAILL
-
Brain kininogen following experimental brain injury: evidence for a secondary eventELLIS, ELLIS; CHAO, CHAO; HEIZER, HEIZER
-
Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different speciesFELETOU, FELETOU; GERMAIN, GERMAIN; THURIEAU, THURIEAU; FAUCHERE, FAUCHERE; CANET, CANET
-
Bradykinin and neuronal injuryFRANCEL, FRANCEL
-
The effect of bradykinin and its fragments on the arachidonate cascade of brain microvesselsGECSE, GECSE; MEZEI, MEZEI; TELEGDY, TELEGDY
-
Contribution of cerebral edema to the neuronal salvage elicited by stimulation of cerebellar fastigial nucleus after occlusion of the middle cerebral artery in ratGOLANOV, GOLANOV; REIS, REIS
-
Bradykinin B2, but not B1, receptor antagonism has a neuroprotective effect after brain injuryGORLACH, GORLACH; HORTOBAGYI, HORTOBAGYI; HORTOBAGYI, HORTOBAGYI; BENYO, BENYO; RELTON, RELTON; WHALLEY, WHALLEY; WAHL, WAHL
-
Bradykinin dilates rat middle cerebral artery and its large branches via endothelial B2 receptors and release of nitric oxideGORLACH, GORLACH; WAHL, WAHL
-
Human neutrophils contain and bind high molecular weight kininogenGUSTAFSON, GUSTAFSON; SCHMAIER, SCHMAIER; WACHTFOGEL, WACHTFOGEL; KAUFMAN, KAUFMAN; KUCICH, KUCICH; COLMAN, COLMAN
-
Distribution of bradykinin B2 receptors in target cells of kinin action. Visualization of the receptor protein in A431 cells, neutrophils and kidney sectionsHAASEMANN, HAASEMANN; FIGUEROA, FIGUEROA; HENDERSON, HENDERSON; GRIGORIEV, GRIGORIEV; ABD ALLA, ABD ALLA; GONZALEZ, GONZALEZ; DUNIA, DUNIA; HOEBEKE, HOEBEKE; JARNAGIN, JARNAGIN; CARTAUD, CARTAUD
-
High‐dose glucocorticoid treatment improves neurological recovery in head‐injured miceHALL, HALL
-
Ischemic brain edema and the osmotic gradient between blood and brainHATASHITA, HATASHITA; HOFF, HOFF; SALAMAT, SALAMAT
-
Hoe 140 a new potent and long acting bradykinin‐antagonist: in vitro studiesHOCK, HOCK; WIRTH, WIRTH; ALBUS, ALBUS; LINZ, LINZ; GERHARDS, GERHARDS; WIEMER, WIEMER; HENKE, HENKE; BREIPOHL, BREIPOHL; KONIG, KONIG; KNOLLE, KNOLLE
-
Autoradiographic localization of binding sites for neuropeptide Y and bradykinin on astrocytesHOSLI, HOSLI; HOSLI, HOSLI
-
Simple quantitative evaluation of blood–brain barrier disruption in vasogenic brain edemaIKEDA, IKEDA; WANG, WANG; NAKAZAWA, NAKAZAWA
-
Neuroligand‐evoked calcium‐dependent release of excitatory amino acids from cultured astrocytesJEFTINIJA, JEFTINIJA; JEFTINIJA, JEFTINIJA; STEFANOVIC, STEFANOVIC; LIU, LIU
-
Expression of c‐fos mRNA after a mild focal cerebral ischemia in SOD‐1 transgenic miceKAMII, KAMII; KINOUCHI, KINOUCHI; SHARP, SHARP; EPSTEIN, EPSTEIN; SAGAR, SAGAR; CHAN, CHAN
-
The role of bradykinin in mediating ischemic brain edema in ratsKAMIYA, KAMIYA; KATAYAMA, KATAYAMA; KASHIWAGI, KASHIWAGI; TERASHI, TERASHI
-
LF 16‐0687 Ms, a bradykinin B2 receptor antagonist, reduces brain edema and improves long‐term neurological function recovery after closed head trauma in ratsKAPLANSKI, KAPLANSKI; PRUNEAU, PRUNEAU; ASA, ASA; ARTRU, ARTRU; AZEZ, AZEZ; IVASHKOVA, IVASHKOVA; RUDICH, RUDICH; SHAPIRA, SHAPIRA
-
Subarachnoid hemorrhage and endothelial L‐arginine pathway in small brain stem arteries in dogsKATUSIC, KATUSIC; MILDE, MILDE; COSENTINO, COSENTINO; MITROVIC, MITROVIC
-
Immunohistochemical demonstration of tissue kallikrein in the neurons of rat brainKIZUKI, KIZUKI; SUZUKI, SUZUKI; KUDO, KUDO; NOGUCHI, NOGUCHI
-
Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and strokeKOCHANEK, KOCHANEK; HALLENBECK, HALLENBECK
-
Influence of the bradykinin B2‐receptor‐antagonist CP‐0597 on the cerebral microcirculation and outcome on global cerebral ischemiaLEHMBERG, LEHMBERG; BECK, BECK; BAETHMANN, BAETHMANN; UHL, UHL
-
Influence of the bradykinin B1/B2‐receptor‐antagonist B 9430 on the cerebral microcirculation and outcome of gerbils from global cerebral ischemiaLEHMBERG, LEHMBERG; BECK, BECK; BAETHMANN, BAETHMANN; UHL, UHL
-
Association of immune responses and ischemic brain infarction in ratLIAO, LIAO; CHEN, CHEN; RAUNG, RAUNG; KUO, KUO; CHEN, CHEN
-
The kallikrein–kinin system as mediator in vasogenic brain edema. Part 2: studies on kinin formation in focal and perifocal brain tissueMAIER‐HAUFF, MAIER‐HAUFF; BAETHMANN, BAETHMANN; LANGE, LANGE; SCHURER, SCHURER; UNTERBERG, UNTERBERG
-
Kininogen consumption in cerebral circulation of humans during brain ischemia and postischemic reperfusionMAKEVNINA, MAKEVNINA; LOMOVA, LOMOVA; ZUBKOVYUN, ZUBKOVYUN; SEMENYUTIN, SEMENYUTIN
-
Kinin B1 receptors: a reviewMARCEAU, MARCEAU
-
Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: effect of neutrophil depletion on extracellular ascorbyl radical formationMATSUO, MATSUO; KIHARA, KIHARA; IKEDA, IKEDA; NINOMIYA, NINOMIYA; ONODERA, ONODERA; KOGURE, KOGURE
-
Cultured endothelial cells synthesize both platelet‐activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphateMCINTYRE, MCINTYRE; ZIMMERMAN, ZIMMERMAN; SATOH, SATOH; PRESCOTT, PRESCOTT
-
Glutamate‐mediated astrocyte‐neuron signallingPARPURA, PARPURA; BASARSKY, BASARSKY; LIU, LIU; JEFTINIJA, JEFTINIJA; JEFTINIJA, JEFTINIJA; HAYDON, HAYDON
-
Role of bradykinin B2 receptors in the formation of vasogenic brain edema in ratsPLESNILA, PLESNILA; SCHULZ, SCHULZ; STOFFEL, STOFFEL; ERISKAT, ERISKAT; PRUNEAU, PRUNEAU; BAETHMANN, BAETHMANN
-
Effect of LF 16‐0687 MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head traumaPRUNEAU, PRUNEAU; CHORNY, CHORNY; BENKOVITZ, BENKOVITZ; ARTRU, ARTRU; ROITBLAT, ROITBLAT; SHAPIRA, SHAPIRA
-
Pharmacological profile of LF 16‐0687, a new potent non‐peptide bradykinin B2 receptor antagonistPRUNEAU, PRUNEAU; PAQUET, PAQUET; LUCCARINI, LUCCARINI; DEFRENE, DEFRENE; FOUCHET, FOUCHET; FRANCK, FRANCK; LOILLIER, LOILLIER; ROBERT, ROBERT; BELICHARD, BELICHARD; DUCLOS, DUCLOS; CREMERS, CREMERS; DODEY, DODEY
-
LF 16‐0687, a new potent non‐peptide bradykinin B2 receptor antagonistPRUNEAU, PRUNEAU; PAQUET, PAQUET; LUCCARINI, LUCCARINI; DEFRENE, DEFRENE; FOUCHET, FOUCHET; FRANCK, FRANCK; LOILLIER, LOILLIER; ROBERT, ROBERT
-
The importance of kinin antagonist treatment timing in closed head traumaRACHINSKY, RACHINSKY; PRUNEAU, PRUNEAU; ARTRU, ARTRU; KAPULER, KAPULER; ALONCHIN, ALONCHIN; SMOLANEZKI, SMOLANEZKI; SHAPIRA, SHAPIRA
-
Kinin receptors on human neuronesRAIDOO, RAIDOO; BHOOLA, BHOOLA
-
Pathophysiology of the kallikrein–kinin system in mammalian nervous tissueRAIDOO, RAIDOO; BHOOLA, BHOOLA
-
Regional distribution of tissue kallikrein in the human brainRAIDOO, RAIDOO; RAMSAROOP, RAMSAROOP; NAIDOO, NAIDOO; BHOOLA, BHOOLA
-
Bradykinin receptors and their antagonistsREGOLI, REGOLI; NSA ALLOGHO, NSA ALLOGHO; RIZZI, RIZZI; GOBEIL, GOBEIL
-
CP‐0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusionRELTON, RELTON; BECKEY, BECKEY; HANSON, HANSON; WHALLEY, WHALLEY
-
Hydroxyl radical mediates the endothelium‐dependent relaxation produced by bradykinin in mouse cerebral arteriolesROSENBLUM, ROSENBLUM
-
Bradykinin mediates P‐selectin expression in rat gastrointestinal microcirculationROZSA, ROZSA; RUSSELL, RUSSELL; SALTER, SALTER; GRANGER, GRANGER
-
Glutamate release from adult primary sensory neurons in culture is modulated by growth factorsRYDH‐RINDER, RYDH‐RINDER; KEREKES, KEREKES; SVENSSON, SVENSSON; HOKFELT, HOKFELT
-
Production of platelet‐activating factor by porcine brain microvascular endothelial cells in cultureSATOH, SATOH; YOSHIDA, YOSHIDA; IMAIZUMI, IMAIZUMI; KOYAMA, KOYAMA; TAKAMATSU, TAKAMATSU
-
LF16‐0687 a novel non‐peptide bradykinin B2 receptor antagonist reduces vasogenic brain edema from a focal lesion in ratsSCHULZ, SCHULZ; PLESNILA, PLESNILA; ERISKAT, ERISKAT; STOFFEL, STOFFEL; PRUNEAU, PRUNEAU; BAETHMANN, BAETHMANN
-
Bradykinin induces interleukin‐6 expression in astrocytes through activation of nuclear factor‐kappaBSCHWANINGER, SCHWANINGER; SALLMANN, SALLMANN; PETERSEN, PETERSEN; SCHNEIDER, SCHNEIDER; PRINZ, PRINZ; LIBERMANN, LIBERMANN; SPRANGER, SPRANGER
-
Concentration‐dependent effects of bradykinin on leukocyte recruitment and venular hemodynamics in rat mesenterySHIGEMATSU, SHIGEMATSU; ISHIDA, ISHIDA; GUTE, GUTE; KORTHUIS, KORTHUIS
-
Mechanisms of bradykinin‐induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channelsSOBEY, SOBEY; HEISTAD, HEISTAD; FARACI, FARACI
-
Cerebrospinal fluid cytology after strokeSORNAS, SORNAS; OSTLUND, OSTLUND; MULLER, MULLER
-
Bradykinin 2 receptor antagonist LF 16‐0687Ms reduces posttraumatic brain edemaSTOVER, STOVER; DOHSE, DOHSE; UNTERBERG, UNTERBERG
-
The kallikrein–kinin system as mediator in vasogenic brain edema. Part 1: cerebral exposure to bradykinin and plasmaUNTERBERG, UNTERBERG; BAETHMANN, BAETHMANN
-
The kallikrein–kinin system as mediator in vasogenic brain edema. Part 3: inhibition of the kallikrein–kinin system in traumatic brain swellingUNTERBERG, UNTERBERG; DAUTERMANN, DAUTERMANN; BAETHMANN, BAETHMANN; MULLERESTER, MULLERESTER
-
Effects of bradykinin on permeability and diameter of pial vessels in vivoUNTERBERG, UNTERBERG; WAHL, WAHL; BAETHMANN, BAETHMANN
-
Neuroprotective effect of LF 16‐0687 Ms, a bradykinin B2 receptor antagonist, on a model of traumatic brain injury in miceVERRECCHIA, VERRECCHIA; MESENGE, MESENGE; PLOTKINE, PLOTKINE
-
Activation of the tissue kallikrein–kinin system in strokeWAGNER, WAGNER; KALB, KALB; LUKOSAVA, LUKOSAVA; HILGENFELDT, HILGENFELDT; SCHWANINGER, SCHWANINGER
-
Vasomotor and permeability effects of bradykinin in the cerebral microcirculationWAHL, WAHL; WHALLEY, WHALLEY; UNTERBERG, UNTERBERG; SCHILLING, SCHILLING; PARSONS, PARSONS; BAETHMANN, BAETHMANN; YOUNG, YOUNG
-
Kinins and kinin receptors in the nervous systemWALKER, WALKER; PERKINS, PERKINS; DRAY, DRAY
-
Analysis of bradykinin receptor mediating relaxation of cat cerebral arteries in vivo and in vitroWHALLEY, WHALLEY; WAHL, WAHL
-
DesArg9‐D‐Arg(Hyp3,Thi5,D‐Tic7, Oic8)bradykinin (desArg10‐(Hoe140)) is a potent bradykinin B1 receptor antagonistWIRTH, WIRTH; BREIPOHL, BREIPOHL; STECHL, STECHL; KNOLLE, KNOLLE; HENKE, HENKE; SCHOLKENS, SCHOLKENS
-
Effects of LF 16‐0687 Ms, a bradykinin B(2) receptor antagonist, on brain edema formation and tissue damage in a rat model of temporary focal cerebral ischemiaZAUSINGER, ZAUSINGER; LUMENTA, LUMENTA; PRUNEAU, PRUNEAU; SCHMID‐ELSAESSER, SCHMID‐ELSAESSER; PLESNILA, PLESNILA; BAETHMANN, BAETHMANN
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