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Letter: gluten digestion in the stomach and duodenum by Aspergillus niger ‐derived enzyme – things to ponder. Authors’ reply

Letter: gluten digestion in the stomach and duodenum by Aspergillus niger ‐derived enzyme –... Sirs , We thank Dr Srinivas for his interest in our recent publication. In our study, we investigated the efficacy of Aspergillus niger prolyl endoprotease (AN‐PEP) on gluten degradation in healthy volunteers. We administered a gluten meal with AN‐PEP intragastrically via a nasoduodenal catheter. This does not represent a fully physiological meal setting, in which a solid meal and AN‐PEP would be ingested separately and undergo the normal physiological digestion processes in the stomach. AN‐PEP has been developed as a dietary supplement that supports the digestion of incidental and/or inadvertent gluten in gluten‐sensitive individuals. Thus, to optimise AN‐PEP for clinical application we believe it is important that future studies investigate the efficacy in an actual meal setting, in which participants consume a meal containing a specified amount of gluten, together with an AN‐PEP supplement. We propose ingestion of AN‐PEP just prior to, or at start of, the meal and not too long before, in order to guarantee optimal efficacy. Future studies will have to focus on AN‐PEP efficacy in gluten‐sensitive individuals. Dr Srinivas noted that there is almost instantaneous gluten digestion with AN‐PEP, regardless of meal type. This raises the question whether the ratio between enzyme concentration and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alimentary Pharmacology & Therapeutics Wiley

Letter: gluten digestion in the stomach and duodenum by Aspergillus niger ‐derived enzyme – things to ponder. Authors’ reply

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Publisher
Wiley
Copyright
Copyright © 2015 John Wiley & Sons Ltd
ISSN
0269-2813
eISSN
1365-2036
DOI
10.1111/apt.13382
pmid
26331568
Publisher site
See Article on Publisher Site

Abstract

Sirs , We thank Dr Srinivas for his interest in our recent publication. In our study, we investigated the efficacy of Aspergillus niger prolyl endoprotease (AN‐PEP) on gluten degradation in healthy volunteers. We administered a gluten meal with AN‐PEP intragastrically via a nasoduodenal catheter. This does not represent a fully physiological meal setting, in which a solid meal and AN‐PEP would be ingested separately and undergo the normal physiological digestion processes in the stomach. AN‐PEP has been developed as a dietary supplement that supports the digestion of incidental and/or inadvertent gluten in gluten‐sensitive individuals. Thus, to optimise AN‐PEP for clinical application we believe it is important that future studies investigate the efficacy in an actual meal setting, in which participants consume a meal containing a specified amount of gluten, together with an AN‐PEP supplement. We propose ingestion of AN‐PEP just prior to, or at start of, the meal and not too long before, in order to guarantee optimal efficacy. Future studies will have to focus on AN‐PEP efficacy in gluten‐sensitive individuals. Dr Srinivas noted that there is almost instantaneous gluten digestion with AN‐PEP, regardless of meal type. This raises the question whether the ratio between enzyme concentration and

Journal

Alimentary Pharmacology & TherapeuticsWiley

Published: Oct 1, 2015

References