LETHAL ACTION OF ULTRAVIOLET AND VISIBLE (BLUE‐VIOLET) RADIATIONS AT DEFINED WAVELENGTHS ON HUMAN LYMPHOBLASTOID CELLS: ACTION SPECTRA AND INTERACTION SITES

LETHAL ACTION OF ULTRAVIOLET AND VISIBLE (BLUE‐VIOLET) RADIATIONS AT DEFINED WAVELENGTHS ON... Abstract— The repair proficient human lymphoblastoid line (TK6) has been employed to construcr an action spectrum for the lethal action of ultraviolet (UV) radiation in the range254–434 nm and to examine possible interactions between longer (334, 365 and 405 nm) and shorter wavelength (254 and 313 nm) radiations. The action spectrum follows a DNA absorption spectrum fairly closely out to 360 nm. As in previously determined lethal action spectra for procaryotic and eucaryotic cell populations, there is a broad shoulder in the334–405 nm region which could reflect the existence of either (a) a non‐DNA chromophore or (b) a unique photochemical reaction in the DNA over this region. Pre‐treatment with radiation at 334 or 365 nm causes either a slight sensitivity to (low fluences) or protection from (higher fluences) subsequent exposure to radiation at a shorter wavelength (254 or 313 nm). Pre‐irradiation at a visible wavelength (405 nm) at all fluence levels employed sensitizes the populations to treatment with 254 or 313 nm radiations. These interactions will influence the lethal outcome of cellular exposure to broad‐band radiation sources. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Photochemistry & Photobiology Wiley

LETHAL ACTION OF ULTRAVIOLET AND VISIBLE (BLUE‐VIOLET) RADIATIONS AT DEFINED WAVELENGTHS ON HUMAN LYMPHOBLASTOID CELLS: ACTION SPECTRA AND INTERACTION SITES

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Publisher
Wiley
Copyright
Copyright © 1984 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0031-8655
eISSN
1751-1097
DOI
10.1111/j.1751-1097.1984.tb03426.x
Publisher site
See Article on Publisher Site

Abstract

Abstract— The repair proficient human lymphoblastoid line (TK6) has been employed to construcr an action spectrum for the lethal action of ultraviolet (UV) radiation in the range254–434 nm and to examine possible interactions between longer (334, 365 and 405 nm) and shorter wavelength (254 and 313 nm) radiations. The action spectrum follows a DNA absorption spectrum fairly closely out to 360 nm. As in previously determined lethal action spectra for procaryotic and eucaryotic cell populations, there is a broad shoulder in the334–405 nm region which could reflect the existence of either (a) a non‐DNA chromophore or (b) a unique photochemical reaction in the DNA over this region. Pre‐treatment with radiation at 334 or 365 nm causes either a slight sensitivity to (low fluences) or protection from (higher fluences) subsequent exposure to radiation at a shorter wavelength (254 or 313 nm). Pre‐irradiation at a visible wavelength (405 nm) at all fluence levels employed sensitizes the populations to treatment with 254 or 313 nm radiations. These interactions will influence the lethal outcome of cellular exposure to broad‐band radiation sources.

Journal

Photochemistry & PhotobiologyWiley

Published: Feb 1, 1984

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