Laparoscopic versus open surgery for rectal cancer after neoadjuvant chemoradiation: Long‐term outcomes of a propensity score matched study

Laparoscopic versus open surgery for rectal cancer after neoadjuvant chemoradiation: Long‐term... INTRODUCTIONThe safety and short‐term benefits of laparoscopic surgery for rectal cancer when compared to open surgery has been demonstrated in many randomized controlled trials. The long‐term results of some of these trials were published recently which showed similar oncological outcomes between the laparoscopic and open arms. Neoadjuvant chemoradiation (NCRT) is recommended for most patients with locally advanced mid and lower third rectal cancers since it has better local control and a superior toxicity profile when compared to adjuvant chemoradiation. Only one randomized trial till date, the Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial has shown that laparoscopic surgery has similar disease‐free survival (DFS) when compared to open surgery in patients who have received NCRT.However, the primary end‐points in this trial as in the others that reported on oncological outcomes were the 3‐year DFS or local recurrence rates. It is now known that following NCRT local recurrence may be delayed, with nearly a quarter of them occurring beyond 5 years. Therefore, it has been suggested that patients who receive NCRT need to have a long‐term follow‐up beyond 5 years to assess the treatment effects, especially on local control. Hence, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Laparoscopic versus open surgery for rectal cancer after neoadjuvant chemoradiation: Long‐term outcomes of a propensity score matched study

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24868
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONThe safety and short‐term benefits of laparoscopic surgery for rectal cancer when compared to open surgery has been demonstrated in many randomized controlled trials. The long‐term results of some of these trials were published recently which showed similar oncological outcomes between the laparoscopic and open arms. Neoadjuvant chemoradiation (NCRT) is recommended for most patients with locally advanced mid and lower third rectal cancers since it has better local control and a superior toxicity profile when compared to adjuvant chemoradiation. Only one randomized trial till date, the Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial has shown that laparoscopic surgery has similar disease‐free survival (DFS) when compared to open surgery in patients who have received NCRT.However, the primary end‐points in this trial as in the others that reported on oncological outcomes were the 3‐year DFS or local recurrence rates. It is now known that following NCRT local recurrence may be delayed, with nearly a quarter of them occurring beyond 5 years. Therefore, it has been suggested that patients who receive NCRT need to have a long‐term follow‐up beyond 5 years to assess the treatment effects, especially on local control. Hence, the

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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