ABBREVIATIONSCIHRCanadian Institutes of Health ResearchKTknowledge translationKtoAknowledge‐to‐actionClinical research provides new knowledge with the goal not only to inform, but also to impact patient health so that the most effective and safe care approaches are adopted. Clinical research can elucidate which clinical care options are appropriate for implementation and which ones are not effective or potentially harmful. For example, in transfusion medicine the historical teaching of transfusing 2 units of red blood cells (RBCs) at a time is not supported by evidence; liberal transfusion does not benefit patients or confer good quality care. Indeed, the Choosing Wisely program identifies several common care options—some that are costly—that should be “deimplemented” or avoided because there is a lack of evidence of effectiveness.Despite considerable resources used in the creation and interpretation of research results, only 14% of medical research findings are implemented to benefit patients. Often, implementation of clinical research evidence is arbitrary and unsystematic, and it may take a mean of 17 years from the time of discovery to effective application. This significant delay denies the patient treatments of proven benefit. Thus, while knowing the best care options is an important first step, knowledge alone is insufficient in ensuring that clinicians and the
Transfusion – Wiley
Published: Jan 1, 2018
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