Access the full text.
Sign up today, get DeepDyve free for 14 days.
V. Mueller-Lessmann, A. Behrendt, W. Wetzel, K. Petersen, D. Anders (2001)
Orofacial findings in the Klippel-Trénaunay syndrome.International journal of paediatric dentistry, 11 3
Q. Wang, A. Timur, P. Szafranski, A. Sadgephour, V. Jurecic, J. Cowell, A. Baldini, D. Driscoll (2001)
Identification and molecular characterization of de novo translocation t(8;14)(q22.3;q13) associated with a vascular and tissue overgrowth syndromeCytogenetic and Genome Research, 95
O Enjolras, JB Mulliken (1998)
Vascular tumors and vascular malformations, 13
T. Furukawa, A. Igata, Y. Toyokura (1970)
Ikeda S: Sturge-Weber and Klippel-Trénaunay syndrome with nevus of ota and ito.Archives of dermatology, 102 6
R. Happle (1987)
Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin.Journal of the American Academy of Dermatology, 16 4
K. Kondo, K. Tanaka, T. Fujii, S. Akita (1997)
Klippel-Trenaunay-Weber syndrome associated with intra-abdominal lymphangioma requiring multiple surgical interventions.Annals of plastic surgery, 39 4
A. Neubert, M. Golden, N. Rose (1995)
KASABACH‐MERRITT COAGULOPATHY COMPLICATING KLIPPEL‐TRENAUNAY‐WEBER SYNDROME IN PREGNANCYObstetrics & Gynecology, 85
E. Jones, M. Orkin (1989)
Tufted angioma (angioblastoma)Journal of The American Academy of Dermatology, 20
S. Lindenauer (1965)
The Klippel‐Trenaunay Syndrome: Varicosity, Hypertrophy and Hemangioma With No Arteriovenous FistulaAnnals of Surgery, 162
F Arrighi (1960)
Hamartose ecto‐mesodérmique: Un cas de fusion de maladie de Recklinghausen (avec éléphantiasis nevromateux de Virchow) et de maladie de Klippel‐Trénaunay‐Parks Weber, 67
A. Whelan, M. Watson, F. Porter, R. Steiner (1995)
Klippel-Trenaunay-Weber syndrome associated with a 5:11 balanced translocation.American journal of medical genetics, 59 4
A. Burns, L. Kaplan, J. Mulliken (1991)
Is there an association between hemangioma and syndromes with dysmorphic features?Pediatrics, 88 6
P. Perkins, S. Weiss (1996)
Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior.The American journal of surgical pathology, 20 10
C. You, J. Rees, D. Gillis, J. Steeves (1983)
Klippel-Trenaunay syndrome: a review.Canadian journal of surgery. Journal canadien de chirurgie, 26 5
P. Baskerville, J. Ackroyd, N. Browse (1985)
The etiology of the Klippel-Trenaunay syndrome.Annals of Surgery, 202
G. Fait, Y. Daniel, M. Kupferminc, I. Gull, M. Peyser, J. Lessing (1996)
Klippel-Trénaunay-Weber syndrome associated with fetal growth restriction.Human reproduction, 11 11
O'Connor Ps, Smith Jl (1978)
Optic nerve variant in the Klippel-Trenaunay-Weber syndrome.Annals of Ophthalmology, 10
O. Enjolras, M. Wassef, É. Mazoyer, I. Frieden, P. Rieu, L. Drouet, A. Taïeb, J. Stalder, J. Escande (1997)
Infants with Kasabach-Merritt syndrome do not have "true" hemangiomas.The Journal of pediatrics, 130 4
O. Norwood, M. Everett (1964)
CARDIAC FAILURE DUE TO ENDOCRINE DEPENDENT HEMANGIOMAS.Archives of dermatology, 89
Molly Sarkar, J. Mulliken, H. Kozakewich, R. Robertson, P. Burrows (1997)
Thrombocytopenic Coagulopathy (Kasabach‐Merritt Phenomenon) Is Associated with Kaposiform Hemangioendothelioma and Not with Common Infantile HemangiomaPlastic and Reconstructive Surgery, 100
Anila Jacob, D. Driscoll, W. Shaughnessy, A. Stanson, R. Clay, P. Gloviczki (1998)
Klippel-Trénaunay syndrome: spectrum and management.Mayo Clinic proceedings, 73 1
G. Bonse (1951)
Röntgenbefunde bei einer PhakomatoseFortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin, 74
D. Paladini, A. Lamberti, A. Teodoro, M. Liguori, M. D'armiento, P. Capuano, P. Martinelli (1998)
Prenatal diagnosis and hemodynamic evaluation of Klippel‐Trenaunay‐Weber syndromeUltrasound in Obstetrics and Gynecology, 12
O. Enjolras, J. Mulliken (1997)
Vascular tumors and vascular malformations (new issues).Advances in dermatology, 13
J. Mulliken (1993)
Cutaneous vascular anomalies.Seminars in vascular surgery, 6 4
G. Aelvoet, P. Jorens, L. Roelen (1991)
Genetic aspects of the Klippel–Trenaunay syndromeBritish Journal of Dermatology, 126
H. Schönenberg, M. Redemann (1972)
[Klippel-Trenaunay-Weber syndrome].Klinische Padiatrie, 184 6
C. James, J. Allison, M. Waner (1999)
Pediatric case of the day. Klippel-Trénaunay syndrome.Radiographics : a review publication of the Radiological Society of North America, Inc, 19 4
N. Craven, A. Wright (1995)
Familial Klippel–Trenaunay syndrome: a case reportClinical and Experimental Dermatology, 20
M. Servelle (1985)
Klippel and Trénaunay's syndrome. 768 operated cases.Annals of Surgery, 201
J. Mulliken, J. Glowacki (1982)
Hemangiomas and Vascular Malformations in Infants and Children: A Classification Based on Endothelial CharacteristicsPlastic and Reconstructive Surgery, 69
Rudolf Happle (1993)
Klippel‐Trenaunay syndrome: is it a paradominant trait?British Journal of Dermatology, 128
S. Weiss, F. Enzinger (1986)
Spindle Cell Hemangioendothelioma: A Low-Grade Angiosarcoma Resembling a Cavernous Hemangioma and Kaposi's SarcomaThe American Journal of Surgical Pathology, 10
R. Roberts, J. Dickinson, P. Hugo, A. Barker (1999)
Prenatal sonographic appearances of Klippel–Trenaunay–Weber syndromePrenatal Diagnosis, 19
W. Martin, K. Ismail, V. Brace, L. Mcpherson, S. Chapman, M. Kilby (2001)
Klippel–Trenaunay–Weber (KTW) syndrome: the use of in utero magnetic resonance imaging (MRI) in a prospective diagnosisPrenatal Diagnosis, 21
M. Cohen (1998)
Some neoplasms and some hamartomatous syndromes: genetic considerations.International journal of oral and maxillofacial surgery, 27 5
T. Furukawa, A. Igata, Y. Toyokura, S. Ikeda (1970)
Sturge-Weber and Klippel-Trenaunay Syndrome With Nevus of Ota and ItoArchives of Dermatology, 102
J. Mulliken, J. Glowacki (1982)
Classification of pediatric vascular lesions.Plastic and reconstructive surgery, 70 1
Z. M.SAMUELL.SPIT, Dr Samuel (1995)
Klippel‐Trenaunay syndrome: Clinical features, complications and management in childrenBritish Journal of Surgery, 82
José Ceballos-Quintal, Doris Pinto-Escalante, Ileana Castillo-Zapata (1996)
A new case of Klippel-Trenaunay-Weber (KTW) syndrome: evidence of autosomal dominant inheritance.American journal of medical genetics, 63 3
G Bonse (1951)
Röntgenbefunde bei einer Phakomatose (Sturge‐Weber kombiniert mit Klippel‐Trénaunay), 74
L. Zukerberg, B. Nickoloff, S. Weiss (1993)
Kaposiform Hemangioendothelioma of Infancy and Childhood: An Aggressive Neoplasm Associated with Kasabach-Merritt Syndrome and LymphangiomatosisThe American Journal of Surgical Pathology, 17
M. Zoppi, R. Ibba, M. Floris, M. Putzolu, G. Crisponi, G. Monni (2001)
Prenatal sonographic diagnosis of Klippel‐Trénaunay‐Weber syndrome with cardiac failureJournal of Clinical Ultrasound, 29
M. Gourie‐Devi, B. Prakash (1978)
Vertebral and epidural hemangioma with paraplegia in Klippel-Trenaunay-Weber syndrome. Case report.Journal of neurosurgery, 48 5
G. Koch (1956)
Zur Klinik, Symptomatologie, Pathogenese und Erbpathologie des Klippel-Trénaunay-Weber-schen SyndromsActa geneticae medicae et gemellologiae, 5
D. Robertson (1956)
Congenital Arteriovenous Fistulae of the ExtremitiesPostgraduate Medical Journal, 33
S. Mahmoud, Mohamed El-Benhawi, M. El-Tonsy, S.M. Kalantar (1988)
Klippel-Trenaunay syndrome.Journal of the American Academy of Dermatology, 18 5 Pt 2
B. Walder, D. Kapelanski, W. Auger, P. Fedullo (2000)
Successful pulmonary thromboendarterectomy in a patient with Klippel-Trenaunay syndrome.Chest, 117 5
<h5>INTRODUCTION</h5> Klippel‐Trenaunay syndrome is an important vascular disorder that is often misunderstood in some quarters. Here I define Klippel‐Trenaunay syndrome, distinguish vascular malformations from vascular tumors, and challenge four commonly held conceptions about Klippel‐Trenaunay syndrome. <h5>KLIPPEL‐TRENAUNAY SYNDROME DEFINED</h5> Klippel‐Trenaunay syndrome 1 consists of 1) combined vascular malformations of the capillary, venous, and lymphatic types, 2 2) varicosities of unusual distribution, in particular the lateral venous anomaly (Fig. 1 ) observed during infancy or childhood, and 3) limb enlargement. Males and females are equally affected. The lower limb is involved in almost 95% of patients, the upper limb accounting for about 5% of patients. Approximately 15% have combined upper and lower limb involvement. Uncommonly, patients may have trunk involvement only [Young, 1988 ; Servelle, 1985 ; Lindenauer, 1965 ; Samuel and Spitz, 1995 ]. Well over 1,500 cases have been recorded [Lindenauer, 1965; Samuel and Spitz, 1995 ; Servelle, 1985 ; Young, 1988 ] (J.B. Mulliken, personal communication, 1999). Servelle [ 1985 ] alone documented 768 operated patients. 1 Diagram of lateral venous anomaly. From Young [ 1988 ]. Varicosities in Klippel‐Trenaunay syndrome differ from commonly occurring varicose veins in two ways. The distribution is different, being more extensive,
American Journal of Medical Genetics Part A – Wiley
Published: Jul 31, 2002
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.