IntroductionChronic pain management remains a challenge for physicians (Argoff et al., ; Birklein et al., ; Finnerup et al., ), particularly as available treatments are only modestly effective in reducing pain. According to a recent meta‐analysis on pharmacotherapy for neuropathic pain, the number needed to treat (NNT) for commonly prescribed drugs ranged from 3 to 6 for a defined goal of just 30 to 50% reduction in pain intensity (Finnerup et al., ). Antidepressants (tricyclics, serotonin and norepinephrine reuptake inhibitors), anti‐epileptics (gabapentin, pregabalin) and opioid agents are commonly prescribed drugs. Unfortunately, they are frequently associated with side effects that result in reduced dosages and limited efficacy (Finnerup et al., ). As a consequence, discovering new medications and exploring optimal pharmacological associations are still significant fields of research in chronic pain management.Ketamine, an NMDA antagonist and anaesthetic agent, was first synthesized in 1962 and is still in use today (Iacobucci et al., ). It is commonly employed as an antihyperalgesia agent intraoperatively and perioperatively (Aveline et al., ; Angst and Clark, ; Abrishamkar et al., ). Given that chronic pain pathophysiology involves glutamate receptor activation, and particularly NMDA receptors (Nijs et al., ; Niesters and Dahan, ; Niesters et al., ; Colloca et al., ), many articles have been published over
European Journal of Pain – Wiley
Published: Jan 1, 2018
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