JOINT DESTRUCTION IN ARTHRITIS: METALLOPROTEINASES IN THE SPOTLIGHT CONSTANCE E . BRINCKERHOFF The erosion of connective tissue (cartilage, tendon, and bone) that accompanies both rheumatoid arthritis (RA) and osteoarthritis (OA) is, unfortunately, well known to physicians and patients alike. This destruction is mediated largely by collagenase and stromelysin, enzymes that are produced by the synovial fibroblasts (1). Collagenase is rate limiting in collagen degradation, while stromelysin degrades noncollagen proteins, e.g., laminin, fibronectin, and proteoglycans. Both enzymes belong to the gene family of metalloproteinases, which comprises at least 10 members (2). All metalloproteinases are active at neutral pH, contain zinc as an integral part of their structure, require Ca++ for activity, and are inhibited by tissue inhibitor of metalloproteinases (TIMP). Thus, TIMP, also a product of synovial fibroblasts, provides a potential mechanism for controlling degradation of the extracellular matrix, but its actual role in modulating disease has been debated. Until now, most of our information on the biochemical and biologic features of these enzymes has been derived from in vitro studies utilizing either From the Department of Medicine and the Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire. Supported by NIH grant AR-26599 and by grants from the
Arthritis & Rheumatology – Wiley
Published: Oct 7, 1991
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera