VOLUME 109 NUMBER 2 FEBRUARY 2018 Biopolymers Biopolymers WWW.WILEYONLINELIBRARY.COM/BIP Autologous bone grafting is often used to treat bone defects; however, a limited supply of bone grafts, long complicated surgical procedures, and concomitant complications have prompted scientists to find alternatives. Dmitri Ossipov et al. report the preparation and in vitro degradation of two types of disulfide cross-linked hyaluronan hydrogels, with and without bisphosphonate conjugated to the polysaccharide, as a potential scaffold for bone tissue engineering. The relationship between hydrogel degradability and capacity for in situ biomineralization is discussed and they show that the expected degradation products are well-tolerated by C2C12 cells. Axel T. Brunger Roger Goody Horst Kessler Stanley J. Opella Bjorn Torger Stokke EDITOR-IN-CHIEF Stanford University Max Planck Institute Munich Center of University of California, Norwegian University of Hilary J. Crichton Stanford, CA, U.S.A. Dortmund, Germany Molecular Life Sciences San Diego Science & Technology Garching, Germany La Jolla, CA, U.S.A. Trondheim, Norway Christian Griesinger Charles M. Deber Max Planck Institute Dinshaw J. Patel Toru Kitagawa Junichi Takagi University of Toronto ASSOCIATE EDITOR Gottingen, Germany Sloan-Kettering Institute University College Osaka University Toronto, Canada Conor H. Doss New York, NY, U.S.A. London Osaka, Japan Peter Dervan Helmut Grubmuller € London, England
Biopolymers – Wiley
Published: Jan 1, 2018
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