183Copper efflux transporters ATP7A and ATP7B: novel biomarkers for platinum drug resistance and targets for therapyYue‐Qin Li, Ji‐Ye Yin, Zhao‐Qian Liu, Xiang‐Ping LiATP7A and ATP7B may be used as potential biomarkers to predict the sensitivity of platinum‐based chemotherapy in numerous malignancies and as therapeutic targets for reversing drug resistance. They mediate platinum drug resistance through three possible mechanisms: binding or sequestration of platinum drugs, facilitating the efflux of platinum drugs, intracellular copper levels modulate platinum drug resistance. In addition to platinum drug resistance, ATP7A and ATP7B may be involved in cancer progression .192mRNA‐Independent Way to Regulate Translation Elongation Rate in Eukaryotic CellsBoris Negrutskii, Dmytro Vlasenko, Marc Mirande, Pavlo Futernyk, Anna El skayaThe exit rate of translation elongation factor eEF1A*GDP from the 80S ribosome is suggested to depend on the protein affinity to specific aminoacyl‐tRNA remaining on the ribosome after GTP hydrolysis. Subsequently, a slower dissociation of eEF1A*GDP from certain aminoacyl‐tRNAs in the ribosome can negatively influence the ribosomal elongation rate in a tRNA‐dependent and mRNA‐independent way. The specific tRNA‐dependent departure rate of eEF1A*GDP from the ribosome is proposed to be a novel factor contributing to the translation elongation control in eukaryotes .REFERENCESLi, Y‐Q., Yin, J‐Y., Liu, Z‐Q., and Li, X‐P. Copper Efflux Transporters ATP7A and ATP7B: Novel Biomarkers for Platinum Drug Resistance and Targets for Therapy. IUBMB Life. 2018, 70, 183–191.Negrutskii, B., Vlasenko, D., Marc, M., Futernyk, P., and El skaya, A. mRNA‐Independent Way to Regulate Translation Elongation Rate in Eukaryotic Cells. IUBMB Life. 2018, 70, 192–196.
IUBMB Life – Wiley
Published: Jan 1, 2018
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