The isothiazolinones methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), MCI/MI 3:1, benzisothiazolinone (BIT), octylisothiazolinone (OIT) and dichlorooctylisothiazolinone (DCOIT) (see Table for further information) are preservatives used in a wide range of industrial chemical products (as biocides) and partly (MCI and MI) in cosmetic and household products, owing to their activity against bacteria and fungi .Current classification as skin sensitizers (H317, formerly R43) of the isothiazolinones in this study; concentration limits for classification and for additional labelling provisions (EUH208) Common abbreviation(s)CAS no.Classification as Skin Sens. H317Harmonized or notifiedCategory or subcategoryConcentration limit for classification (%)Concentration limit for EUH208BIT2634‐33‐5Harmonized1≥ 0.05≥ 1/10 of the concentration limit for classificationDCOIT64359‐81‐5Notified1, 1A≥ 1, ≥ 0.1MI; MIT2682‐20‐4Notified1, 1A≥ 1, ≥ 0.1MCI; CMIT26172‐55‐4Notified1, 1A, 1B≥ 1, ≥ 0.1MCI/MI (3:1); CMIT/MIT (3:1)55965‐84‐9Harmonized1≥ 0.0015OIT26530‐20‐1Harmonized1≥ 0.05BIT, benzisothiazolinone; DCOIT, dichlorooctylisothiazolinone; MI or MIT, methylisothiazolinone; MCI or CMIT, methylchloroisothiazolinone; MCI/MI (3:1) or CMIT/MIT (3:1), reaction mass of methylchloroisothiazolinone and methylisothiazolinone (3:1); OIT, octylisothiazolinone.EUH208, additional labelling provision to protect already sensitized individuals: ‘Contains (name of sensitising substance). May produce an allergic reaction’.Committee for Risk Assessment opinion on MI: subcategory 1A, specific concentration limit for classification: ≥ 0.0015%.Although isothiazolinones have been recognized since the 1970s as contact allergens, and the use of MCI/MI (e.g. Kathon® CG) resulted in an epidemic of contact allergy in the 1980s, it is the
Contact Dermatitis – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera