Isothiazolinones are still widely used in paints purchased in five European countries: a follow‐up study

Isothiazolinones are still widely used in paints purchased in five European countries: a... The isothiazolinones methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), MCI/MI 3:1, benzisothiazolinone (BIT), octylisothiazolinone (OIT) and dichlorooctylisothiazolinone (DCOIT) (see Table  for further information) are preservatives used in a wide range of industrial chemical products (as biocides) and partly (MCI and MI) in cosmetic and household products, owing to their activity against bacteria and fungi .Current classification as skin sensitizers (H317, formerly R43) of the isothiazolinones in this study; concentration limits for classification and for additional labelling provisions (EUH208) Common abbreviation(s)CAS no.Classification as Skin Sens. H317Harmonized or notifiedCategory or subcategoryConcentration limit for classification (%)Concentration limit for EUH208BIT2634‐33‐5Harmonized1≥ 0.05≥ 1/10 of the concentration limit for classificationDCOIT64359‐81‐5Notified1, 1A≥ 1, ≥ 0.1MI; MIT2682‐20‐4Notified1, 1A≥ 1, ≥ 0.1MCI; CMIT26172‐55‐4Notified1, 1A, 1B≥ 1, ≥ 0.1MCI/MI (3:1); CMIT/MIT (3:1)55965‐84‐9Harmonized1≥ 0.0015OIT26530‐20‐1Harmonized1≥ 0.05BIT, benzisothiazolinone; DCOIT, dichlorooctylisothiazolinone; MI or MIT, methylisothiazolinone; MCI or CMIT, methylchloroisothiazolinone; MCI/MI (3:1) or CMIT/MIT (3:1), reaction mass of methylchloroisothiazolinone and methylisothiazolinone (3:1); OIT, octylisothiazolinone.EUH208, additional labelling provision to protect already sensitized individuals: ‘Contains (name of sensitising substance). May produce an allergic reaction’.Committee for Risk Assessment opinion on MI: subcategory 1A, specific concentration limit for classification: ≥ 0.0015%.Although isothiazolinones have been recognized since the 1970s as contact allergens, and the use of MCI/MI (e.g. Kathon® CG) resulted in an epidemic of contact allergy in the 1980s, it is the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Contact Dermatitis Wiley

Isothiazolinones are still widely used in paints purchased in five European countries: a follow‐up study

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0105-1873
eISSN
1600-0536
D.O.I.
10.1111/cod.12937
Publisher site
See Article on Publisher Site

Abstract

The isothiazolinones methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), MCI/MI 3:1, benzisothiazolinone (BIT), octylisothiazolinone (OIT) and dichlorooctylisothiazolinone (DCOIT) (see Table  for further information) are preservatives used in a wide range of industrial chemical products (as biocides) and partly (MCI and MI) in cosmetic and household products, owing to their activity against bacteria and fungi .Current classification as skin sensitizers (H317, formerly R43) of the isothiazolinones in this study; concentration limits for classification and for additional labelling provisions (EUH208) Common abbreviation(s)CAS no.Classification as Skin Sens. H317Harmonized or notifiedCategory or subcategoryConcentration limit for classification (%)Concentration limit for EUH208BIT2634‐33‐5Harmonized1≥ 0.05≥ 1/10 of the concentration limit for classificationDCOIT64359‐81‐5Notified1, 1A≥ 1, ≥ 0.1MI; MIT2682‐20‐4Notified1, 1A≥ 1, ≥ 0.1MCI; CMIT26172‐55‐4Notified1, 1A, 1B≥ 1, ≥ 0.1MCI/MI (3:1); CMIT/MIT (3:1)55965‐84‐9Harmonized1≥ 0.0015OIT26530‐20‐1Harmonized1≥ 0.05BIT, benzisothiazolinone; DCOIT, dichlorooctylisothiazolinone; MI or MIT, methylisothiazolinone; MCI or CMIT, methylchloroisothiazolinone; MCI/MI (3:1) or CMIT/MIT (3:1), reaction mass of methylchloroisothiazolinone and methylisothiazolinone (3:1); OIT, octylisothiazolinone.EUH208, additional labelling provision to protect already sensitized individuals: ‘Contains (name of sensitising substance). May produce an allergic reaction’.Committee for Risk Assessment opinion on MI: subcategory 1A, specific concentration limit for classification: ≥ 0.0015%.Although isothiazolinones have been recognized since the 1970s as contact allergens, and the use of MCI/MI (e.g. Kathon® CG) resulted in an epidemic of contact allergy in the 1980s, it is the

Journal

Contact DermatitisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ; ;

References

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