The isothiazolinones methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), MCI/MI 3:1, benzisothiazolinone (BIT), octylisothiazolinone (OIT) and dichlorooctylisothiazolinone (DCOIT) (see Table for further information) are preservatives used in a wide range of industrial chemical products (as biocides) and partly (MCI and MI) in cosmetic and household products, owing to their activity against bacteria and fungi .Current classification as skin sensitizers (H317, formerly R43) of the isothiazolinones in this study; concentration limits for classification and for additional labelling provisions (EUH208) Common abbreviation(s)CAS no.Classification as Skin Sens. H317Harmonized or notifiedCategory or subcategoryConcentration limit for classification (%)Concentration limit for EUH208BIT2634‐33‐5Harmonized1≥ 0.05≥ 1/10 of the concentration limit for classificationDCOIT64359‐81‐5Notified1, 1A≥ 1, ≥ 0.1MI; MIT2682‐20‐4Notified1, 1A≥ 1, ≥ 0.1MCI; CMIT26172‐55‐4Notified1, 1A, 1B≥ 1, ≥ 0.1MCI/MI (3:1); CMIT/MIT (3:1)55965‐84‐9Harmonized1≥ 0.0015OIT26530‐20‐1Harmonized1≥ 0.05BIT, benzisothiazolinone; DCOIT, dichlorooctylisothiazolinone; MI or MIT, methylisothiazolinone; MCI or CMIT, methylchloroisothiazolinone; MCI/MI (3:1) or CMIT/MIT (3:1), reaction mass of methylchloroisothiazolinone and methylisothiazolinone (3:1); OIT, octylisothiazolinone.EUH208, additional labelling provision to protect already sensitized individuals: ‘Contains (name of sensitising substance). May produce an allergic reaction’.Committee for Risk Assessment opinion on MI: subcategory 1A, specific concentration limit for classification: ≥ 0.0015%.Although isothiazolinones have been recognized since the 1970s as contact allergens, and the use of MCI/MI (e.g. Kathon® CG) resulted in an epidemic of contact allergy in the 1980s, it is the
Contact Dermatitis – Wiley
Published: Jan 1, 2018
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