1 It has been previously shown that spreading neuronal activation can generate a cortical spreading ischaemia (CSI) in rats. The purpose of the present study was to investigate whether vasodilators cause CSI to revert to a normal cortical spreading depression (CSD). 2 A KCl‐induced CSD travelled from an open cranial window to a closed window where the cortex was superfused with physiological artificial cerebrospinal fluid (ACSF). At the closed window, recordings revealed a short‐lasting negative slow potential shift accompanied by a variable, small and short initial hypoperfusion followed by hyperaemia and then oligaemia. 3 In contrast, spreading neuronal activation locally induced CSI at the closed window when ACSF contained a NO. synthase (NOS) inhibitor, NG‐nitro‐l‐arginine, and an increased K+ concentration ((K+)ACSF). CSI was characterised by a sharp and prolonged initial cerebral blood flow decrease to 29 ± 11 % of the baseline and a prolonged negative potential shift. 4 Co‐application of a NO. donor, S‐nitroso‐N‐acetylpenicillamine, and NOS inhibitor with high (K+)ACSF re‐established a short‐lasting negative potential shift and spreading hyperaemia typical of CSD. Similarly, the NO.‐independent vasodilator papaverine caused CSI to revert to a pattern characteristic of CSD. 5 In acute rat brain slices, NOS inhibition and high (K+)ACSF did not prolong the negative slow potential shift compared to that induced by high (K+)ACSF alone. 6 The data indicate that the delayed recovery of the slow potential was caused by vasoconstriction during application of high (K+)ACSF and a NOS inhibitor in vivo. This supports the possibility of a vicious circle: spreading neuronal activation induces vasoconstriction, and vasoconstriction prevents repolarisation during CSI. Speculatively, this pathogenetic process could be involved in migraine‐induced stroke.
The Journal of Physiology – Wiley
Published: Mar 1, 2001
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera