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Is there a predisposition for meiotic non-disjunciton that may be detected by mitoitc hyperploidy?

Is there a predisposition for meiotic non-disjunciton that may be detected by mitoitc hyperploidy? The aneuploidy frequencies have been stuided in vitro in lymphocytes from couples with recurent abortions, from parents of a trisomic child and from control couples with at least two normal children; c-heterochromatin variants have been analysed on the same samples by length measurements. A significant increase of hyeperploid cells has been observed in the lymphocytes from parents of a trisomic and couples with recurrent abortions as well. However, no consistent correlation has been found so far between c-heterochromatin varients and an increase of aneuploidy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Genetics Wiley

Is there a predisposition for meiotic non-disjunciton that may be detected by mitoitc hyperploidy?

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References (18)

Publisher
Wiley
Copyright
1983 Blackwell Munksgaard
ISSN
0009-9163
eISSN
1399-0004
DOI
10.1111/j.1399-0004.1983.tb02237.x
Publisher site
See Article on Publisher Site

Abstract

The aneuploidy frequencies have been stuided in vitro in lymphocytes from couples with recurent abortions, from parents of a trisomic child and from control couples with at least two normal children; c-heterochromatin variants have been analysed on the same samples by length measurements. A significant increase of hyeperploid cells has been observed in the lymphocytes from parents of a trisomic and couples with recurrent abortions as well. However, no consistent correlation has been found so far between c-heterochromatin varients and an increase of aneuploidy.

Journal

Clinical GeneticsWiley

Published: Sep 1, 1983

Keywords: Aneuploidy; c-heterochromation varients; hyperploidy.

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