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Is Sirt1 a miracle bullet for longevity?

Is Sirt1 a miracle bullet for longevity? Summary The Sir2 (silent information regulator 2) family of nicotinamide adenine dinucleotide-dependent deacetylases has been implicated in the regulation of aging and longevity across a wide variety of organisms. Although controversial, Sir2 proteins have also been implicated as key mediators for the beneficial effects of caloric restriction (CR) on aging and longevity. In this issue, Bordone et al. report that transgenic mice in which the mammalian Sir2 ortholog Sirt1 is overexpressed mimic the physiological changes in response to CR. These findings have important implications for the development of CR mimetics and perhaps also for lifespan extension. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Aging Cell Wiley

Is Sirt1 a miracle bullet for longevity?

Aging Cell , Volume 6 (6) – Dec 1, 2007
3 pages

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References (19)

Publisher
Wiley
Copyright
© 2007 The Author Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2007
ISSN
1474-9718
DOI
10.1111/j.1474-9726.2007.00344.x
pmid
17941969
Publisher site
See Article on Publisher Site

Abstract

Summary The Sir2 (silent information regulator 2) family of nicotinamide adenine dinucleotide-dependent deacetylases has been implicated in the regulation of aging and longevity across a wide variety of organisms. Although controversial, Sir2 proteins have also been implicated as key mediators for the beneficial effects of caloric restriction (CR) on aging and longevity. In this issue, Bordone et al. report that transgenic mice in which the mammalian Sir2 ortholog Sirt1 is overexpressed mimic the physiological changes in response to CR. These findings have important implications for the development of CR mimetics and perhaps also for lifespan extension.

Journal

Aging CellWiley

Published: Dec 1, 2007

Keywords: aging; caloric restriction; metabolism; NAD-dependent deacetylase; Sirt1; transgenic mice

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