Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Baur, D. Sinclair (2006)
Therapeutic potential of resveratrol: the in vivo evidenceNature Reviews Drug Discovery, 5
L. Bordone, Maria Motta, F. Picard, Ashley Robinson, U. Jhala, Javier Apfeld, T. McDonagh, M. Lemieux, M. McBurney, A. Szilvasi, Erin Easlon, Su-Ju Lin, L. Guarente (2005)
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β CellsPLoS Biology, 4
G. Blander, L. Guarente (2004)
The Sir2 family of protein deacetylases.Annual review of biochemistry, 73
Javier Revollo, Andrew Grimm, S. Imai (2007)
The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammalsCurrent Opinion in Gastroenterology, 23
F. Picard, Martin Kurtev, Namjin Chung, A. Topark-ngarm, T. Senawong, R. Oliveira, M. Leid, M. McBurney, L. Guarente (2004)
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γNature, 429
Javier Revollo, Andrew Grimm, S. Imai (2004)
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells*Journal of Biological Chemistry, 279
B. Dasgupta, J. Milbrandt (2007)
Resveratrol stimulates AMP kinase activity in neuronsProceedings of the National Academy of Sciences, 104
J. Rodgers, C. Lerín, W. Haas, S. Gygi, B. Spiegelman, P. Puigserver (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1Nature, 434
Kathryn Moynihan, Andrew Grimm, Marie Plueger, E. Bernal-Mizrachi, Eric Ford, C. Cras-Méneur, M. Permutt, S. Imai (2005)
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.Cell metabolism, 2 2
V. Longo, B. Kennedy (2006)
Sirtuins in Aging and Age-Related DiseaseCell, 126
Kathryn Moynihan, S. Imai (2006)
Sirt1 as a key regulator orchestrating the response to caloric restrictionDrug Discovery Today: Disease Mechanisms, 3
K. Howitz, Kevin Bitterman, H. Cohen, Dudley Lamming, Siva Lavu, Jason Wood, R. Zipkin, Phuong Chung, A. Kisielewski, Li-li Zhang, Brandy Scherer, D. Sinclair (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 425
Marie Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Gény, M. Laakso, P. Puigserver, J. Auwerx (2006)
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1αCell, 127
Z. Gerhart-Hines, J. Rodgers, Olivia Baré, C. Lerin, Seung-hee Kim, R. Mostoslavsky, F. Alt, Zhidan Wu, P. Puigserver (2007)
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1αThe EMBO Journal, 26
Danica Chen, Andrew Steele, S. Lindquist, L. Guarente (2005)
Increase in Activity During Calorie Restriction Requires Sirt1Science, 310
Danica Chen, L. Guarente (2007)
SIR2: a potential target for calorie restriction mimetics.Trends in molecular medicine, 13 2
L. Bordone, Dena Cohen, Ashley Robinson, Maria Motta, Ed Veen, A. Czopik, Andrew Steele, Hayley Crowe, S. Marmor, Jianyuan Luo, W. Gu, L. Guarente (2007)
SIRT1 transgenic mice show phenotypes resembling calorie restrictionAging Cell, 6
M. Haigis, L. Guarente (2006)
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.Genes & development, 20 21
M. Lane, A. Black, A. Handy, E. Tilmont, D. Ingram, G. Roth (2001)
Caloric Restriction in PrimatesAnnals of the New York Academy of Sciences, 928
Summary The Sir2 (silent information regulator 2) family of nicotinamide adenine dinucleotide-dependent deacetylases has been implicated in the regulation of aging and longevity across a wide variety of organisms. Although controversial, Sir2 proteins have also been implicated as key mediators for the beneficial effects of caloric restriction (CR) on aging and longevity. In this issue, Bordone et al. report that transgenic mice in which the mammalian Sir2 ortholog Sirt1 is overexpressed mimic the physiological changes in response to CR. These findings have important implications for the development of CR mimetics and perhaps also for lifespan extension.
Aging Cell – Wiley
Published: Dec 1, 2007
Keywords: aging; caloric restriction; metabolism; NAD-dependent deacetylase; Sirt1; transgenic mice
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.