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We tested (in an inhibitory avoidance test) ramipril and the n‐octyl‐ester of ramipril (RA‐octil; Hoe 065), which was shown to have no significant influence on plasma‐converting enzyme (CE) activity or blood pressure in spontaneously hypertensive rats. In addition, the influence of the specific NO‐synthase inhibitor NG‐nitro‐L‐arginine (L‐NNA) and the specific B2 antagonist Hoe 140 in combination with ramipril and RA‐octil were tested. Ramipril and RA‐octil showed a significant prolongation of step‐through latencies. L‐NNA and Hoe 140 by themselves showed no effects. The combination of ramipril and of RA‐octil, respectively, with L‐NNA or Hoe 140 did not produce any prolongation of step‐through latencies. © 1992 Wiley‐Liss, Inc. © 1992 Wiley‐Liss, Inc.
Drug Development Research – Wiley
Published: Jan 1, 1992
Keywords: Hoe 140; nitric oxide; N G ‐nitro‐ L ‐arginine; memory
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