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Involvement of nitric oxide formation in the action of ramipril and ramipril‐octil in an inhibitory avoidance task in mice

Involvement of nitric oxide formation in the action of ramipril and ramipril‐octil in an... We tested (in an inhibitory avoidance test) ramipril and the n‐octyl‐ester of ramipril (RA‐octil; Hoe 065), which was shown to have no significant influence on plasma‐converting enzyme (CE) activity or blood pressure in spontaneously hypertensive rats. In addition, the influence of the specific NO‐synthase inhibitor NG‐nitro‐L‐arginine (L‐NNA) and the specific B2 antagonist Hoe 140 in combination with ramipril and RA‐octil were tested. Ramipril and RA‐octil showed a significant prolongation of step‐through latencies. L‐NNA and Hoe 140 by themselves showed no effects. The combination of ramipril and of RA‐octil, respectively, with L‐NNA or Hoe 140 did not produce any prolongation of step‐through latencies. © 1992 Wiley‐Liss, Inc. © 1992 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Development Research Wiley

Involvement of nitric oxide formation in the action of ramipril and ramipril‐octil in an inhibitory avoidance task in mice

Drug Development Research , Volume 27 (3) – Jan 1, 1992

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References (28)

Publisher
Wiley
Copyright
Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
ISSN
0272-4391
eISSN
1098-2299
DOI
10.1002/ddr.430270303
Publisher site
See Article on Publisher Site

Abstract

We tested (in an inhibitory avoidance test) ramipril and the n‐octyl‐ester of ramipril (RA‐octil; Hoe 065), which was shown to have no significant influence on plasma‐converting enzyme (CE) activity or blood pressure in spontaneously hypertensive rats. In addition, the influence of the specific NO‐synthase inhibitor NG‐nitro‐L‐arginine (L‐NNA) and the specific B2 antagonist Hoe 140 in combination with ramipril and RA‐octil were tested. Ramipril and RA‐octil showed a significant prolongation of step‐through latencies. L‐NNA and Hoe 140 by themselves showed no effects. The combination of ramipril and of RA‐octil, respectively, with L‐NNA or Hoe 140 did not produce any prolongation of step‐through latencies. © 1992 Wiley‐Liss, Inc. © 1992 Wiley‐Liss, Inc.

Journal

Drug Development ResearchWiley

Published: Jan 1, 1992

Keywords: Hoe 140; nitric oxide; N G ‐nitro‐ L ‐arginine; memory

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