Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats

Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in... We assessed the effect of a 35‐day delayed intracerebroventricular (ICV) infusion of epidermal growth factor (EGF) on the survival and function of the substantia nigra (SN) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. EGF infusion for 28 days resulted in a twofold increase in the number of surviving tyrosine‐hydroxylase (TH)–positive SN neurons and a significant increase in ipsilateral striatal TH‐positive fiber staining compared to controls at 200 days following the injury. In addition, there was a persistent enhancement of behavioral recovery, as indicated by a reduction in amphetamine‐induced rotations. We conclude that EGF exerts a neurotrophic effect on the dopaminergic neurons in this experimental model of parkinsonism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Movement Disorders Wiley

Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats

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Publisher
Wiley
Copyright
Copyright © 1991 Movement Disorder Society
ISSN
0885-3185
eISSN
1531-8257
D.O.I.
10.1002/mds.870060403
Publisher site
See Article on Publisher Site

Abstract

We assessed the effect of a 35‐day delayed intracerebroventricular (ICV) infusion of epidermal growth factor (EGF) on the survival and function of the substantia nigra (SN) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. EGF infusion for 28 days resulted in a twofold increase in the number of surviving tyrosine‐hydroxylase (TH)–positive SN neurons and a significant increase in ipsilateral striatal TH‐positive fiber staining compared to controls at 200 days following the injury. In addition, there was a persistent enhancement of behavioral recovery, as indicated by a reduction in amphetamine‐induced rotations. We conclude that EGF exerts a neurotrophic effect on the dopaminergic neurons in this experimental model of parkinsonism.

Journal

Movement DisordersWiley

Published: Jan 1, 1991

References

  • Epidermal growth factor induces tyrosine hydroxylase in clonal pheochromocytoma cell line PC‐G2
    Goodman, Goodman; Slater, Slater; Herschman, Herschman

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