KeypointsIntravenous opioid drug abuse (IVDA) was previously correlated with laryngeal cancer. Yet, discrimination of this correlation by anatomical subsites has not been described until now.When compared with glottic cancer (G‐SCC), a history of IVDA was found to be a risk factor for supraglottic cancer (SG‐SCC), independent of: smoking, excessive alcohol consumption and socioeconomic status.The odds ratio for patients with an IVDA history to have SG‐SCC relatively to G‐SCC was 10.846 (95% CI:1.3‐89.4).INTRODUCTIONSmoking and increased alcohol consumption are known risk factors for laryngeal squamous cell carcinoma (SCC). In 1946, Slaughter developed the “field cancerisation” theory for head and neck cancers, arguing the entire aerodigestive tract mucosa is exposed to the same carcinogenic agents and carries a common risk for development of cancer. Nevertheless, due to their anatomy and function, different laryngeal sites differ in their exposure to carcinogenic agents. While the glottis is more exposed to inhaled carcinogenic agents, the supraglottis as a junction between the larynx and the pharynx is exposed to both inhaled and ingested agents. Alcohol consumption may affect laryngeal cancer risk through both direct contact and solvent action. Hence, increased alcohol consumption was found to have an enhanced role in carcinogenesis of supraglottic SCC (SG‐SCC) relatively
Clinical Otolaryngology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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