KeypointsIntravenous opioid drug abuse (IVDA) was previously correlated with laryngeal cancer. Yet, discrimination of this correlation by anatomical subsites has not been described until now.When compared with glottic cancer (G‐SCC), a history of IVDA was found to be a risk factor for supraglottic cancer (SG‐SCC), independent of: smoking, excessive alcohol consumption and socioeconomic status.The odds ratio for patients with an IVDA history to have SG‐SCC relatively to G‐SCC was 10.846 (95% CI:1.3‐89.4).INTRODUCTIONSmoking and increased alcohol consumption are known risk factors for laryngeal squamous cell carcinoma (SCC). In 1946, Slaughter developed the “field cancerisation” theory for head and neck cancers, arguing the entire aerodigestive tract mucosa is exposed to the same carcinogenic agents and carries a common risk for development of cancer. Nevertheless, due to their anatomy and function, different laryngeal sites differ in their exposure to carcinogenic agents. While the glottis is more exposed to inhaled carcinogenic agents, the supraglottis as a junction between the larynx and the pharynx is exposed to both inhaled and ingested agents. Alcohol consumption may affect laryngeal cancer risk through both direct contact and solvent action. Hence, increased alcohol consumption was found to have an enhanced role in carcinogenesis of supraglottic SCC (SG‐SCC) relatively
Clinical Otolaryngology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera