Intravenous opioid drug abuse as an independent risk factor for supraglottic squamous cell carcinoma—A case‐control study

Intravenous opioid drug abuse as an independent risk factor for supraglottic squamous cell... KeypointsIntravenous opioid drug abuse (IVDA) was previously correlated with laryngeal cancer. Yet, discrimination of this correlation by anatomical subsites has not been described until now.When compared with glottic cancer (G‐SCC), a history of IVDA was found to be a risk factor for supraglottic cancer (SG‐SCC), independent of: smoking, excessive alcohol consumption and socioeconomic status.The odds ratio for patients with an IVDA history to have SG‐SCC relatively to G‐SCC was 10.846 (95% CI:1.3‐89.4).INTRODUCTIONSmoking and increased alcohol consumption are known risk factors for laryngeal squamous cell carcinoma (SCC). In 1946, Slaughter developed the “field cancerisation” theory for head and neck cancers, arguing the entire aerodigestive tract mucosa is exposed to the same carcinogenic agents and carries a common risk for development of cancer. Nevertheless, due to their anatomy and function, different laryngeal sites differ in their exposure to carcinogenic agents. While the glottis is more exposed to inhaled carcinogenic agents, the supraglottis as a junction between the larynx and the pharynx is exposed to both inhaled and ingested agents. Alcohol consumption may affect laryngeal cancer risk through both direct contact and solvent action. Hence, increased alcohol consumption was found to have an enhanced role in carcinogenesis of supraglottic SCC (SG‐SCC) relatively http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Intravenous opioid drug abuse as an independent risk factor for supraglottic squamous cell carcinoma—A case‐control study

Loading next page...
 
/lp/wiley/intravenous-opioid-drug-abuse-as-an-independent-risk-factor-for-6fvC0xEAi0
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.12990
Publisher site
See Article on Publisher Site

Abstract

KeypointsIntravenous opioid drug abuse (IVDA) was previously correlated with laryngeal cancer. Yet, discrimination of this correlation by anatomical subsites has not been described until now.When compared with glottic cancer (G‐SCC), a history of IVDA was found to be a risk factor for supraglottic cancer (SG‐SCC), independent of: smoking, excessive alcohol consumption and socioeconomic status.The odds ratio for patients with an IVDA history to have SG‐SCC relatively to G‐SCC was 10.846 (95% CI:1.3‐89.4).INTRODUCTIONSmoking and increased alcohol consumption are known risk factors for laryngeal squamous cell carcinoma (SCC). In 1946, Slaughter developed the “field cancerisation” theory for head and neck cancers, arguing the entire aerodigestive tract mucosa is exposed to the same carcinogenic agents and carries a common risk for development of cancer. Nevertheless, due to their anatomy and function, different laryngeal sites differ in their exposure to carcinogenic agents. While the glottis is more exposed to inhaled carcinogenic agents, the supraglottis as a junction between the larynx and the pharynx is exposed to both inhaled and ingested agents. Alcohol consumption may affect laryngeal cancer risk through both direct contact and solvent action. Hence, increased alcohol consumption was found to have an enhanced role in carcinogenesis of supraglottic SCC (SG‐SCC) relatively

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial