Interleukin 6 in Intact and Injured Mouse Peripheral Nerves

Interleukin 6 in Intact and Injured Mouse Peripheral Nerves The multifunctional cytokine interleukin 6 (IL‐6) has direct growth, survival and differentiation effects on peripheral and central neurons. Furthermore, it can modulate the production by non‐neuronal cells of other cytokines and growth factors, and thereby affect nerve cells indirectly. We have studied IL‐6 expression and production in intact and injured peripheral nerves of C57/BL/6NHSD mice, which display the normal rapid progression of Wallerian degeneration. The IL‐6 mRNA was detected in nerves degenerating in vitro or in vivo, but not in intact nerves. In vitro‐ and in vivo‐degenerating nerve segments and neuroma nerve segments synthesized and secreted IL‐6. The onset of IL‐6 production was rapid and prolonged. It was detected as early as 2 h after injury and persisted for the entire period of 21 days tested after the injury. Of the non‐neuronal cells that reside in intact and injured nerves, macrophages and fibroblasts were the major contributors to IL‐6 production. We also studied IL‐6 production in intact and injured nerves of mutant C57BL/6‐WLD/OLA/NHSD mice, which display very slow progression of Wallerian degeneration. Injured nerves of C57BL/6‐WLD/OLA/NHSD mice produced significantly lower amounts of IL‐6 than did rapidly degenerating nerves of C57/BL/6NHSD mice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

Interleukin 6 in Intact and Injured Mouse Peripheral Nerves

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Publisher
Wiley
Copyright
Copyright © 1996 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-816X
eISSN
1460-9568
D.O.I.
10.1111/j.1460-9568.1996.tb01237.x
Publisher site
See Article on Publisher Site

Abstract

The multifunctional cytokine interleukin 6 (IL‐6) has direct growth, survival and differentiation effects on peripheral and central neurons. Furthermore, it can modulate the production by non‐neuronal cells of other cytokines and growth factors, and thereby affect nerve cells indirectly. We have studied IL‐6 expression and production in intact and injured peripheral nerves of C57/BL/6NHSD mice, which display the normal rapid progression of Wallerian degeneration. The IL‐6 mRNA was detected in nerves degenerating in vitro or in vivo, but not in intact nerves. In vitro‐ and in vivo‐degenerating nerve segments and neuroma nerve segments synthesized and secreted IL‐6. The onset of IL‐6 production was rapid and prolonged. It was detected as early as 2 h after injury and persisted for the entire period of 21 days tested after the injury. Of the non‐neuronal cells that reside in intact and injured nerves, macrophages and fibroblasts were the major contributors to IL‐6 production. We also studied IL‐6 production in intact and injured nerves of mutant C57BL/6‐WLD/OLA/NHSD mice, which display very slow progression of Wallerian degeneration. Injured nerves of C57BL/6‐WLD/OLA/NHSD mice produced significantly lower amounts of IL‐6 than did rapidly degenerating nerves of C57/BL/6NHSD mice.

Journal

European Journal of NeuroscienceWiley

Published: Mar 1, 1996

References

  • Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action
    Benveniste, Benveniste
  • B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes
    Lotz, Lotz; Jirik, Jirik; Kabouridis, Kabouridis; Tsoukas, Tsoukas; Hirano, Hirano; Kishimoto, Kishimoto; Carson, Carson
  • Absence of Wallerian degeneration does not hinder regeneration in peripheral nerve
    Lunn, Lunn; Perry, Perry; Brown, Brown; Rosen, Rosen; Gordon, Gordon
  • Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain
    Schobitz, Schobitz; Voorhuis, Voorhuis; Kloet, Kloet

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