Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury Extracts of injured rat brain contained molecules that shared biological and physicochemical properties with interleukin‐1 (IL‐1). Brain IL‐1‐like activity increased following brain injury in parallel with the increase in astrocyte and fibroblast mitogenic activity. After 3 days postlesion, it reached about 20 times the basal (noninjured) level. Monoclonal antibodies to human IL‐1 inhibited this brain IL‐1‐like activity. One of the cellular sources of brain IL‐1‐like activity seems to be astroglial cells. Primary cultures of purified rat brain astrocytes secreted into the culture medium more IL‐1 activity than comparable numbers of peripheral blood monocytes. Brain IL‐1, as well as authentic monocyte IL‐1, appear to act on brain glial cells, promoting thymidine incorporation into purified astrocytes in culture. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Research Wiley

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

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Publisher
Wiley
Copyright
Copyright © 1987 Alan R. Liss, Inc.
ISSN
0360-4012
eISSN
1097-4547
D.O.I.
10.1002/jnr.490170303
Publisher site
See Article on Publisher Site

Abstract

Extracts of injured rat brain contained molecules that shared biological and physicochemical properties with interleukin‐1 (IL‐1). Brain IL‐1‐like activity increased following brain injury in parallel with the increase in astrocyte and fibroblast mitogenic activity. After 3 days postlesion, it reached about 20 times the basal (noninjured) level. Monoclonal antibodies to human IL‐1 inhibited this brain IL‐1‐like activity. One of the cellular sources of brain IL‐1‐like activity seems to be astroglial cells. Primary cultures of purified rat brain astrocytes secreted into the culture medium more IL‐1 activity than comparable numbers of peripheral blood monocytes. Brain IL‐1, as well as authentic monocyte IL‐1, appear to act on brain glial cells, promoting thymidine incorporation into purified astrocytes in culture.

Journal

Journal of Neuroscience ResearchWiley

Published: Jan 1, 1987

References

  • Interleukin 1 of the central nervous system is produced by ameboid microglia
    Giulian, Giulian; Baker, Baker; Shih, Shih; Lachman, Lachman
  • Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
    McCarthy, McCarthy; de Vellis, de Vellis
  • In vitro rapid organization of endothelial cells into capillary‐like networks is promoted by collagen matrices
    Montesano, Montesano; Orci, Orci; Vassalli, Vassalli

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