Interference between non‐a, non‐b and hepatitis b virus infection in chimpanzees

Interference between non‐a, non‐b and hepatitis b virus infection in chimpanzees Pre‐existing chronic or concurrent acute non‐A, non‐B (NANB) virus infection has been found to interfere with hepatitis B virus (HBV) replication and to delay and moderate markedly the appearance of disease related to HBV infection in chimpanzees. The mechanism for this phenomenon remains unclear. These findings are of practical significance for vaccine safety testing and evaluation of methods for virus inactivation in chimpanzees. The possible occurrence of dual NANB and HBV infection requires that prolonged follow‐up be carried out. Attempts to carry out inactivation studies on materials containing both types of virus may also provide misleading observations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Interference between non‐a, non‐b and hepatitis b virus infection in chimpanzees

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Abstract

Pre‐existing chronic or concurrent acute non‐A, non‐B (NANB) virus infection has been found to interfere with hepatitis B virus (HBV) replication and to delay and moderate markedly the appearance of disease related to HBV infection in chimpanzees. The mechanism for this phenomenon remains unclear. These findings are of practical significance for vaccine safety testing and evaluation of methods for virus inactivation in chimpanzees. The possible occurrence of dual NANB and HBV infection requires that prolonged follow‐up be carried out. Attempts to carry out inactivation studies on materials containing both types of virus may also provide misleading observations.

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 1983

References

  • An assay for the detection of the DNA genome of hepatitis B virus in serum
    Berninger, Berninger; Hammer, Hammer; Hoyer, Hoyer; Gerin, Gerin

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