Key PointsSerum levels of topiramate, rufinamide, and N‐desmethylclobazam increased in children and adults with increasing CBD doseSerum levels of zonisamide and eslicarbazepine increased in adults with increasing CBD doseAdult participants reported sedation more frequently with higher N‐desmethylclobazam levelsAST and ALT levels were higher in participants taking concomitant valproate with CBDFor millennia, there has been great interest in the use of cannabis and its derivatives in the treatment of various medical and neurologic problems, including epilepsy. Cannabidiol (CBD), a phytocannabinoid compound derived from the cannabis plant, is of particular interest as a potential anticonvulsant due to the reported lack of psychoactive effects compared to those seen in tetrahydrocannabinol (THC). CBD has long been known to be effective in animal models of epilepsy. However, until recently, few data were available regarding its safety and efficacy in humans. Recent placebo‐controlled studies indicate that CBD may be effective for the treatment of difficult‐to‐control epilepsies including Dravet and Lennox‐Gastaut syndromes. These experimental data are supported by observational data from class IV open‐label compassionate‐use CBD state‐sponsored expanded‐access programs, such as the one in Alabama recognized under the name “Carly's Law.”CBD modulates several cytochrome P450 (CYP) enzymes, which are of potential interest in investigating interactions with
Epilepsia – Wiley
Published: Sep 1, 2017
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera