Interaction of Ethanol with Vitamin A

Interaction of Ethanol with Vitamin A Vol. 7, No. I Winter 1983 Interaction of Ethanol with Vitamin A Maria Anna Leo, MD, and Charles S. Lieber. MD HAS BEEN recognized that alcoholics with cirrhosis ITmaytosuffer fromdeficiency.' Recent studies havepossibly night blindness,' which is related vitamin A shown that plasma vitamin A3 as well as retinol-binding protein (RBP) levels4 are decreased in patients with alcoholic cirrhosis. These complications have usually been attributed to malnutrition, since poor dietary intake has been reported in alcoholics with4* or without' cirrhosis. It is also possible that these complications may result from hepatic injury, because decreased plasma vitamin A and RBP levels have been reported in patients with liver disease without apparent alcohol intake.6 These low plasma levels have been postulated to be due to defective synthesis of RBP in the liver.6 Alcoholic cirrhosis is often associated with zinc deficien~y,~~ which has also been postulated to decrease plasma RBP through impaired mobilization of RBP from the liver.7 These classic aspects of vitamin A deficiency due to either poor dietary intake or severe liver disease have been the subject of previous reviews' and will not be discussed here. Instead, we shall focus on information that has recently become available concerning direct http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcoholism: Clinical & Experimental Research Wiley

Interaction of Ethanol with Vitamin A

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Abstract

Vol. 7, No. I Winter 1983 Interaction of Ethanol with Vitamin A Maria Anna Leo, MD, and Charles S. Lieber. MD HAS BEEN recognized that alcoholics with cirrhosis ITmaytosuffer fromdeficiency.' Recent studies havepossibly night blindness,' which is related vitamin A shown that plasma vitamin A3 as well as retinol-binding protein (RBP) levels4 are decreased in patients with alcoholic cirrhosis. These complications have usually been attributed to malnutrition, since poor dietary intake has been reported in alcoholics with4* or without' cirrhosis. It is also possible that these complications may result from hepatic injury, because decreased plasma vitamin A and RBP levels have been reported in patients with liver disease without apparent alcohol intake.6 These low plasma levels have been postulated to be due to defective synthesis of RBP in the liver.6 Alcoholic cirrhosis is often associated with zinc deficien~y,~~ which has also been postulated to decrease plasma RBP through impaired mobilization of RBP from the liver.7 These classic aspects of vitamin A deficiency due to either poor dietary intake or severe liver disease have been the subject of previous reviews' and will not be discussed here. Instead, we shall focus on information that has recently become available concerning direct

Journal

Alcoholism: Clinical & Experimental ResearchWiley

Published: Jan 1, 1983

References

  • Alteration in zinc. vitamin A and retinol‐binding protein in chronic alcoholics: A possible mechanism for night blindness and hypogonadism
    McClain, CJ; Thiel, DH; Parker, S; Badzin, LK; Gilbert, H
  • Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat
    Sato, C; Matsuda, Y; Lieber, CS

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