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References (33)
-
R. Siervogel, John Morrison, Kathe Kelly, M. Mellies, Peter Gartside, Charles Glueck (1980)
Familial hyper‐alpha‐lipoproteinemia in 26 kindredsClinical Genetics, 17
-
Per Magnus, K. Berg, W. Nance (1983)
Predicting zygosity in Norwegian twin pairs born 1915–1960Clinical Genetics, 24
-
J. Pedersen, K. Berg (1988)
Normal DNA polymorphism at the low density lipoprotein receptor (LDLR) locus associated with serum cholesterol levelClinical Genetics, 34
-
P. Röschlau, E. Bernt, W. Gruber (1974)
Enzymatische Bestimmung des Gesamt-Cholesterins im Serum, 12
-
Berg (1981)
117 -
V. Zannis, J. Breslow (1981)
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification.Biochemistry, 20 4
-
Utermann (1984)
232Hum. Genet., 65
-
K. Berg (1987)
Genetic Risk Factors for Atherosclerotic Disease -
E. Southern (1975)
Detection of specific sequences among DNA fragments separated by gel electrophoresis.Journal of molecular biology, 98 3
-
R. Gregg, L. Zech, E. Schaefer, D. Stark, D. Wilson, H. Brewer (1986)
Abnormal in vivo metabolism of apolipoprotein E4 in humans.The Journal of clinical investigation, 78 3
-
Weisgraber (1982)
2518J. Biol. Chem., 257
-
W. Schneider, P. Kovanen, M. Brown, J. Goldstein, G. Utermann, W. Weber, R. Havel, L. Kotite, J. Kane, T. Innerarity, R. Mahley (1981)
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.The Journal of clinical investigation, 68 4
-
A. Cumming, F. Robertson (1984)
Polymorphism at the Apoprotein‐E locus in relation to risk of coronary diseaseClinical Genetics, 25
-
L. Anderson, N. Anderson (1977)
High resolution two-dimensional electrophoresis of human plasma proteins.Proceedings of the National Academy of Sciences of the United States of America, 74 12
-
Sing (1985)
268Am. J. Hum. Genet., 37
-
H. Hobbs, M. Lehrman, Tokuo Yamamoto, D. Russell (1985)
Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.Proceedings of the National Academy of Sciences of the United States of America, 82 22
-
A. BØRresen, K. Berg (1981)
The apoE polymorphism studied by two‐dimensional, high‐resolution gel electrophoresis of serumClinical Genetics, 20
-
G. Utermann, K. Vogelberg, A. Steinmetz, W. Schoenborn, N. Pruin, M. Jaeschke, M. Hees, H. Canzler (1979)
Polymorphism of apolipoprotein EClinical Genetics, 15
-
L. Kunkel, Kirby Smith, S. Boyer, D. Borgaonkar, S. Wachtel, O. Miller, W. Breg, H. Jones, J. Rary (1977)
Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.Proceedings of the National Academy of Sciences of the United States of America, 74 3
-
Utermann (1978)
351Clin. Genet., 14
-
K. Weisgraber, T. Innerarity, R. Mahley (1982)
Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site.The Journal of biological chemistry, 257 5
-
A. Wahlefeld (1974)
Triglycerides Determination after Enzymatic Hydrolysis -
K. Maartmann‐Moe, P. Magnus, Wendy Golden, K. Berg (1981)
Genetics of the low density lipoprotein receptor:Clinical Genetics, 20
-
Church (1984)
1991Proc. Natl. Acad. Sci. USA., 81
-
W. Friedewald, R. Levy, D. Fredrickson (1972)
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.Clinical chemistry, 18 6
-
K. Berg (1984)
Twin studies of coronary heart disease and its risk factors.Acta geneticae medicae et gemellologiae, 33 3
-
Röschlau (1974)
403Z. Klin. Chem. Klin. Biochem., 12
-
Thomas Dayspring (2020)
triglyceridesCatalysis from A to Z
-
C. Sing, J. Davignon (1985)
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation.American journal of human genetics, 37 2
-
(1984)
Apolipoprotein E pheno -
K. Berg (1981)
Twin research in coronary heart disease.Progress in clinical and biological research, 69 Pt C
-
S. Humphries, B. Horsthemke, M. Seed, M. Holm, V. Wynn, A. Kessling, J. Donald, N. Jowett, D. Galton, R. Williamson (1985)
A COMMON DNA POLYMORPHISM OF THE LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR GENE AND ITS USE IN DIAGNOSISThe Lancet, 325
-
S. Rall, K. Weisgraber, T. Innerarity, R. Mahley (1982)
Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.Proceedings of the National Academy of Sciences of the United States of America, 79 15
- Publisher
- Wiley
- Copyright
- 1989 Blackwell Munksgaard
- ISSN
- 0009-9163
- eISSN
- 1399-0004
- DOI
- 10.1111/j.1399-0004.1989.tb02953.x
- Publisher site
- See Article on Publisher Site
Abstract
Subjects drawn from a population-based register were studied with respect to lipid level association. The association of isoforms of apolipoprotein E (apoE) with lipid level in the general population was found to be limited to people with one particular genotype at the low density lipoprotein receptor (LDLR) locus. The results presented in this paper suggest that functional LDLR variants enhance or limit the effect of isoforms of apoE. The association between apoE4 and serum total and LDL cholesterol level may be mediated through the LDL (apoB100, apoE) receptor to a greater extent than previously thought.
Journal
Clinical Genetics – Wiley
Published: May 1, 1989
Keywords: apolipoprotein E; cholesterol; DNA; LDL cholesterol; low density lipoprotein receptor; normal genetic variation; restriction fragment length polymorphism (RFLP)