Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level

Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles... Subjects drawn from a population-based register were studied with respect to lipid level association. The association of isoforms of apolipoprotein E (apoE) with lipid level in the general population was found to be limited to people with one particular genotype at the low density lipoprotein receptor (LDLR) locus. The results presented in this paper suggest that functional LDLR variants enhance or limit the effect of isoforms of apoE. The association between apoE4 and serum total and LDL cholesterol level may be mediated through the LDL (apoB100, apoE) receptor to a greater extent than previously thought. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Genetics Wiley

Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level

Clinical Genetics, Volume 35 (5) – May 1, 1989

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Publisher
Wiley
Copyright
1989 Blackwell Munksgaard
ISSN
0009-9163
eISSN
1399-0004
D.O.I.
10.1111/j.1399-0004.1989.tb02953.x
Publisher site
See Article on Publisher Site

Abstract

Subjects drawn from a population-based register were studied with respect to lipid level association. The association of isoforms of apolipoprotein E (apoE) with lipid level in the general population was found to be limited to people with one particular genotype at the low density lipoprotein receptor (LDLR) locus. The results presented in this paper suggest that functional LDLR variants enhance or limit the effect of isoforms of apoE. The association between apoE4 and serum total and LDL cholesterol level may be mediated through the LDL (apoB100, apoE) receptor to a greater extent than previously thought.

Journal

Clinical GeneticsWiley

Published: May 1, 1989

Keywords: apolipoprotein E; cholesterol; DNA; LDL cholesterol; low density lipoprotein receptor; normal genetic variation; restriction fragment length polymorphism (RFLP)

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