Integration of paper spray ionization high‐field asymmetric waveform ion mobility spectrometry for forensic applications

Integration of paper spray ionization high‐field asymmetric waveform ion mobility spectrometry... INTRODUCTIONWipes or swabs are commonly employed media for surface sampling methods used in forensic sample collection protocols. The preparation of wipes or swabs prior to sampling and the extraction steps needed prior to instrumental analysis can be time‐consuming. In addition, these samples are often quite complex, requiring extensive chromatographic methods for their analysis, which takes more time to complete. A recent focus in mass spectrometric research involves the development of ambient ionization sources in which samples are ionized under ambient conditions with minimal sample preparation that can reduce analysis time. One such technique, paper spray ionization (PSI), developed by Wang et al, is of particular interest. The setup of PSI is simple. In addition, the ionization mechanism is theorized to be the same as electrospray ionization (ESI). Therefore, analyses that are typically performed using ESI could potentially be performed using PSI. Applications of PSI to the analysis of pharmaceuticals in dry blood spots, urine samples, and other samples have been demonstrated. Using such an approach, forensically relevant samples can be analyzed in a quicker fashion. This not only helps to reduce any potential backlogs, but also reduces solvent waste and the overall cost of the analysis.Despite the advantages of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Rapid Communications in Mass Spectrometry Wiley

Integration of paper spray ionization high‐field asymmetric waveform ion mobility spectrometry for forensic applications

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons, Ltd.
ISSN
0951-4198
eISSN
1097-0231
D.O.I.
10.1002/rcm.8068
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONWipes or swabs are commonly employed media for surface sampling methods used in forensic sample collection protocols. The preparation of wipes or swabs prior to sampling and the extraction steps needed prior to instrumental analysis can be time‐consuming. In addition, these samples are often quite complex, requiring extensive chromatographic methods for their analysis, which takes more time to complete. A recent focus in mass spectrometric research involves the development of ambient ionization sources in which samples are ionized under ambient conditions with minimal sample preparation that can reduce analysis time. One such technique, paper spray ionization (PSI), developed by Wang et al, is of particular interest. The setup of PSI is simple. In addition, the ionization mechanism is theorized to be the same as electrospray ionization (ESI). Therefore, analyses that are typically performed using ESI could potentially be performed using PSI. Applications of PSI to the analysis of pharmaceuticals in dry blood spots, urine samples, and other samples have been demonstrated. Using such an approach, forensically relevant samples can be analyzed in a quicker fashion. This not only helps to reduce any potential backlogs, but also reduces solvent waste and the overall cost of the analysis.Despite the advantages of

Journal

Rapid Communications in Mass SpectrometryWiley

Published: Jan 15, 2018

References

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