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10.1002/(SICI)1097-4652(199705)171:2<161::AID-JCP6>3.3.CO;2-5 Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin‐forming or non‐myelin forming mature phenotype. We are interested in the role of insulin‐like growth factor‐I (IGF‐I) in SC development. We have shown previously SCs proliferate in response to IGF‐I in vitro. In the current study, we investigated the role of IGF‐I in SC differentiation. SC differentiation was determined by morphological criteria and expression of myelin proteins. Addition of 1 mM 8‐bromo cyclic AMP (cAMP) or growth on Matrigel matrix decreased proliferation and induced differentiation of SCs. IGF‐I enhanced both cAMP and Matrigel matrix‐induced SC differentiation, as assessed by both morphological criteria and myelin gene expression. Cultured SCs also express IGF binding protein‐5 (IGFBP‐5), which can modulate the actions of IGF‐I. We examined the expression of IGFBP‐5 during SC differentiation. Both cAMP and Matrigel matrix treatment enhanced IGFBP‐5 protein expression and cAMP increased IGFBP‐5 gene expression five fold. These findings suggest IGF‐I potentiates SC differentiation. The concomitant up‐regulation of IGFBP‐5 may play a role in targeting IGF‐I to SCs and thus increase local IGF‐I bioavailability. J. Cell. Physiol. 171:161–167, 1997. © 1997 Wiley‐Liss, Inc.
Journal of Cellular Physiology – Wiley
Published: May 1, 1997
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