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M. Inkster, V. Hinshaw, I. Schulze (1993)
The hemagglutinins of duck and human H1 influenza viruses differ in sequence conservation and in glycosylationJournal of Virology, 67
M. Bańbura, Y. Kawaoka, T. Thomas, R. Webster (1991)
Reassortants with equine 1 (H7N7) influenza virus hemagglutinin in an avian influenza virus genetic background are pathogenic in chickens.Virology, 184 1
F. Hayden (1997)
Antivirals for pandemic influenza.The Journal of infectious diseases, 176 Suppl 1
J. Talon, C. Horvath, R. Polley, C. Basler, T. Muster, P. Palese, A. García-Sastre (2000)
Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 ProteinJournal of Virology, 74
H. Maassab, M. Bryant (1999)
The development of live attenuated cold‐adapted influenza virus vaccine for humansReviews in Medical Virology, 9
D. Kobasa, K. Wells, Y. Kawaoka (2001)
Amino Acids Responsible for the Absolute Sialidase Activity of the Influenza A Virus Neuraminidase: Relationship to Growth in the Duck IntestineJournal of Virology, 75
C. Scholtissek, W. Rohde, V. Hoyningen, R. Rott (1978)
On the origin of the human influenza virus subtypes H2N2 and H3N2.Virology, 87 1
Y. Kawaoka, Y. Kawaoka, O. Gorman, Toshihiro Ito, K. Wells, R. Donis, M. Castrucci, Isabella Donatelli, Robert Webster, Robert Webster (1998)
Influence of host species on the evolution of the nonstructural (NS) gene of influenza A viruses.Virus research, 55 2
P. Suarez, J. Valcárcel, Juan Ortín (1992)
Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutantsJournal of Virology, 66
Toshihiro Ito, J. Couceiro, S. Kelm, L. Baum, S. Krauss, M. Castrucci, I. Donatelli, H. Kida, J. Paulson, R. Webster, R. Webster, Y. Kawaoka, Y. Kawaoka (1998)
Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic PotentialJournal of Virology, 72
W. Weis, W. Weis, Jerry Brown, S. Cusack, S. Cusack, J. Paulson, J. Skehel, D. Wiley (1988)
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acidNature, 333
S. Schultz‐Cherry, V. Hinshaw (1996)
Influenza virus neuraminidase activates latent transforming growth factor betaJournal of Virology, 70
O. Zhirnov, T. Konakova, T. Wolff, H. Klenk (2002)
NS1 Protein of Influenza A Virus Down-Regulates ApoptosisJournal of Virology, 76
M. Matrosovich, A. Tuzikov, N. Bovin, A. Gambaryan, A. Klimov, M. Castrucci, I. Donatelli, Y. Kawaoka (2000)
Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into MammalsJournal of Virology, 74
M. Matrosovich, M. Matrosovich, S. Krauss, R. Webster (2001)
H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity.Virology, 281 2
Xiyan Xu, K. Subbarao, N. Cox, Yuan-ji Guo (1999)
Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong.Virology, 261 1
A. Breuning, C. Scholtissek (1986)
A reassortant between influenza A viruses (H7N2) synthesizing an enzymatically inactive neuraminidase at 40 degrees which is not incorporated into infectious particles.Virology, 150 1
R. Wagner, T. Wolff, A. Herwig, S. Pleschka, H. Klenk (2000)
Interdependence of Hemagglutinin Glycosylation and Neuraminidase as Regulators of Influenza Virus Growth: a Study by Reverse GeneticsJournal of Virology, 74
J. Banks, E. Speidel, E. Moore, L. Plowright, A. Piccirillo, I. Capua, P. Cordioli, A. Fioretti, D. Alexander (2001)
Changes in the haemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in ItalyArchives of Virology, 146
S. Baigent, R. Bethell, John McCauley (1999)
Genetic analysis reveals that both haemagglutinin and neuraminidase determine the sensitivity of naturally occurring avian influenza viruses to zanamivir in vitro.Virology, 263 2
C. Scholtissek, H. Bürger, O. Kistner, K. Shortridge (1985)
The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses.Virology, 147 2
P. Massin, S. Werf, N. Naffakh (2001)
Residue 627 of PB2 Is a Determinant of Cold Sensitivity in RNA Replication of Avian Influenza VirusesJournal of Virology, 75
Claas Claas, Osterhaus Osterhaus, van Beek van Beek, De Jong De Jong, Rimmelzwaan Rimmelzwaan, Senne Senne, Krauss Krauss, Shortridge Shortridge, Webster Webster (1998)
Human influenza A virus (H5N1) related to a highly pathogenic avian influenza virusLancet, 351
Suarez Suarez, Perdue Perdue (1998)
Multiple alignment of the non‐structural genes of influenza A virusesVirus Res, 54
C. Bender, H. Hall, Jing Huang, A. Klimov, N. Cox, A. Hay, V. Gregory, K. Cameron, W. Lim, K. Subbarao (1999)
Characterization of the surface proteins of influenza A (H5N1) viruses isolated from humans in 1997-1998.Virology, 254 1
M. Els, G. Air, K. Murti, R. Webster, W. Laver (1985)
An 18-amino acid deletion in an influenza neuraminidase.Virology, 142 2
M. Perdue, Maricarmen García, D. Senne, M. Fraire (1997)
Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses.Virus research, 49 2
C. Scholtissek, J. Stech, S. Krauss, R. Webster (2002)
Cooperation between the Hemagglutinin of Avian Viruses and the Matrix Protein of Human Influenza A VirusesJournal of Virology, 76
J Treanor, M. Snyder, William London, Brian Murphy (1989)
The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza A virus for squirrel monkeys.Virology, 171 1
N. Naffakh, Pascale Massin, N. Escriou, B. Crescenzo-Chaigne, S. Werf (2000)
Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses.The Journal of general virology, 81 Pt 5
S. Seo, E. Hoffmann, R. Webster (2002)
Lethal H5N1 influenza viruses escape host anti-viral cytokine responsesNature Medicine, 8
J. Dybing, S. Schultz‐Cherry, D. Swayne, D. Suarez, M. Perdue (2000)
Distinct Pathogenesis of Hong Kong-Origin H5N1 Viruses in Mice Compared to That of Other Highly Pathogenic H5 Avian Influenza VirusesJournal of Virology, 74
K. Subbarao, A. Klimov, J. Katz, H. Regnery, W. Lim, H. Hall, M. Perdue, D. Swayne, C. Bender, Jing Huang, M. Hemphill, T. Rowe, Michael Shaw, Xiyan Xu, K. Fukuda, N. Cox (1998)
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.Science, 279 5349
E. O’Neill, S. Krauss, J. Riberdy, R. Webster, D. Woodland (2000)
Heterologous protection against lethal A/HongKong/156/97 (H5N1) influenza virus infection in C57BL/6 mice.The Journal of general virology, 81 Pt 11
S. Seo, M. Peiris, R. Webster (2002)
Protective Cross-Reactive Cellular Immunity to Lethal A/Goose/Guangdong/1/96-Like H5N1 Influenza Virus Is Correlated with the Proportion of Pulmonary CD8+ T Cells Expressing Gamma InterferonJournal of Virology, 76
E. Subbarao, W. London, B. Murphy (1993)
A single amino acid in the PB2 gene of influenza A virus is a determinant of host rangeJournal of Virology, 67
J. Almond (1977)
A single gene determines the host range of influenza virusNature, 270
(1997)
avian influenza virus
H. Scheiblauer, M. Reinacher, M. Tashiro, R. Rott (1992)
Interactions between bacteria and influenza A virus in the development of influenza pneumonia.The Journal of infectious diseases, 166 4
M. Snyder, A. Buckler-White, W. London, E. Tierney, B. Murphy (1987)
The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeysJournal of Virology, 61
Y. Hiromoto, Y. Yamazaki, T. Fukushima, Takehiko Saito, S. Lindstrom, K. Omoe, R. Nerome, W. Lim, S. Sugita, K. Nerome (2000)
Evolutionary characterization of the six internal genes of H5N1 human influenza A virus.The Journal of general virology, 81 Pt 5
Weisan Chen, P. Calvo, D. Malide, J. Gibbs, U. Schubert, I. Bačík, Sameh Basta, R. O'neill, J. Schickli, P. Palese, P. Henklein, J. Bennink, J. Yewdell (2001)
A novel influenza A virus mitochondrial protein that induces cell deathNature Medicine, 7
D. Kobasa, S. Kodihalli, M. Luo, M. Castrucci, I. Donatelli, Yasuo Suzuki, Takashi Suzuki, Y. Kawaoka (1999)
Amino Acid Residues Contributing to the Substrate Specificity of the Influenza A Virus NeuraminidaseJournal of Virology, 73
Peng Gao, Shinji Watanabe, Shinji Watanabe, Toshihiro Ito, H. Goto, K. Wells, M. McGregor, A. Cooley, Y. Kawaoka (1999)
Biological Heterogeneity, Including Systemic Replication in Mice, of H5N1 Influenza A Virus Isolates from Humans in Hong KongJournal of Virology, 73
V. Hinshaw, R. Webster, C. Naeve, B. Murphy (1983)
Altered tissue tropism of human-avian reassortant influenza viruses.Virology, 128 1
J. Blok, G. Air (1982)
Variation in the membrane-insertion and "stalk" sequences in eight subtypes of influenza type A virus neuraminidase.Biochemistry, 21 17
M. Ohuchi, R. Ohuchi, A. Feldmann, H. Klenk (1997)
Regulation of receptor binding affinity of influenza virus hemagglutinin by its carbohydrate moietyJournal of Virology, 71
A. Vines, K. Wells, M. Matrosovich, M. Castrucci, Toshihiro Ito, Y. Kawaoka (1998)
The Role of Influenza A Virus Hemagglutinin Residues 226 and 228 in Receptor Specificity and Host Range RestrictionJournal of Virology, 72
H. Nishimura, S. Itamura, T. Iwasaki, T. Kurata, M. Tashiro (2000)
Characterization of human influenza A (H5N1) virus infection in mice: neuro-, pneumo- and adipotropic infection.The Journal of general virology, 81 Pt 10
Linda Baum, James Paulson (1991)
The N2 neuraminidase of human influenza virus has acquired a substrate specificity complementary to the hemagglutinin receptor specificity.Virology, 180 1
M. Hatta, Peng Gao, P. Halfmann, Y. Kawaoka (2001)
Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A VirusesScience, 293
D. Suarez, M. Perdue (1998)
Multiple alignment comparison of the non-structural genes of influenza A viruses.Virus research, 54 1
Maryna Eichelberger, William Allan, M. Zijlstra, Rudolf Jaenisch, Peter Doherty (1991)
Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cellsThe Journal of Experimental Medicine, 174
B. Fiszon, C. Hannoun, A. García-Sastre, E. Villar, J. Cabezas (1989)
Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses.Research in virology, 140 5
J. Ko, H. Jin, A. Asano, A. Takada, A. Ninomiya, H. Kida, Hironao Hokiyama, M. Ohara, Masaoki Tsuzuki, M. Nishibori, M. Mizutani, Tomomasa Watanabe (2002)
Polymorphisms and the differential antiviral activity of the chicken Mx gene.Genome research, 12 4
J. Skehel, D. Stevens, R. Daniels, A. Douglas, Marcel Knossow, I. Wilson, D. Wiley (1984)
A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody.Proceedings of the National Academy of Sciences of the United States of America, 81 6
Sue Morris, Graeme Price, Jacqueline Barnett, Steven Hiscox, Harry Smith, Clive Sweet (1999)
Role of neuraminidase in influenza virus-induced apoptosis.The Journal of general virology, 80 ( Pt 1)
S. Seo, R. Webster (2001)
Cross-Reactive, Cell-Mediated Immunity and Protection of Chickens from Lethal H5N1 Influenza Virus Infection in Hong Kong Poultry MarketsJournal of Virology, 75
A. Gambaryan, V. Piskarev, I. Yamskov, A. Sakharov, A. Tuzikov, N. Bovin, N. Nifant’ev, M. Matrosovich (1995)
Human influenza virus recognition of sialyloligosaccharidesFEBS Letters, 366
E. Nobusawa, T. Aoyama, H. Kato, Yasuo Suzuki, Y. Tateno, K. Nakajima (1991)
Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses.Virology, 182 2
R. Rott (1992)
The pathogenic determinant of influenza virus.Veterinary microbiology, 33 1-4
Yongxiu Yao, Louise Mingay, J. McCauley, W. Barclay (2001)
Sequences in Influenza A Virus PB2 Protein That Determine Productive Infection for an Avian Influenza Virus in Mouse and Human Cell LinesJournal of Virology, 75
N. Zhou, K. Shortridge, E. Claas, S. Krauss, R. Webster (1999)
Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong KongJournal of Virology, 73
C. Gibson, R. Daniels, J. Oxford, J. McCauley (1992)
Sequence analysis of the equine H7 influenza virus haemagglutinin gene.Virus research, 22 2
M. Shaw, Xiyan Xu, Yan Li, Susan Normand, R. Ueki, G. Kunimoto, H. Hall, A. Klimov, N. Cox, K. Subbarao (2002)
Reappearance and global spread of variants of influenza B/Victoria/2/87 lineage viruses in the 2000-2001 and 2001-2002 seasons.Virology, 303 1
Y. Guan, K. Shortridge, S. Krauss, R. Webster (1999)
Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?Proceedings of the National Academy of Sciences of the United States of America, 96 16
Banks Banks, Speidel Speidel, McCauley McCauley, Alexander Alexander (2000)
Phylogenetic analysis of H7 haemagglutinin subtype influenza A virusesArch Virol, 145
H. Goto, K. Wells, A. Takada, Y. Kawaoka (2001)
Plasminogen-Binding Activity of Neuraminidase Determines the Pathogenicity of Influenza A VirusJournal of Virology, 75
M. Ohuchi, M. Orlich, R. Ohuchi, B. Simpson, W. Garten, H. Klenk, R. Rott (1989)
Mutations at the cleavage site of the hemagglutinin after the pathogenicity of influenza virus A/chick/Penn/83 (H5N2).Virology, 168 2
M. Burnet, P. Lind (1954)
Genetics of Virulence in Influenza VirusesNature, 173
J. Schulman, P. Palese (1977)
Virulence factors of influenza A viruses: WSN virus neuraminidase required for plaque production in MDBK cellsJournal of Virology, 24
Xiuyan Wang, Ming Li, Hongyong Zheng, T. Muster, P. Palese, A. Beg, A. García-Sastre (2000)
Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta InterferonJournal of Virology, 74
G. Rogers, J. Paulson, R. Daniels, J. Skehel, I. Wilson, D. Wiley (1983)
Single amino acid substitutions in influenza haemagglutinin change receptor binding specificityNature, 304
R. Connor, Y. Kawaoka, R. Webster, J. Paulson (1994)
Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates.Virology, 205 1
A. Buckler-White, C. Naeve, B. Murphy (1986)
Characterization of a gene coding for M proteins which is involved in host range restriction of an avian influenza A virus in monkeysJournal of Virology, 57
Yuan Lu, M. Wambach, M. Katze, R. Krug (1995)
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.Virology, 214 1
C. Cheung, L. Poon, A. Lau, W. Luk, Y. Lau, K. Shortridge, S. Gordon, Y. Guan, J. Peiris (2002)
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?The Lancet, 360
T. Saito, K. Kawano (1997)
Loss of glycosylation at Asn144 alters the substrate preference of the N8 influenza A virus neuraminidase.The Journal of veterinary medical science, 59 10
Gambaryan Gambaryan, Piskarev Piskarev, Yamskov Yamskov, Sakharov Sakharov, Tuzikov Tuzikov, Bovin Bovin, Nifant'ev Nifant'ev, Matrosovich Matrosovich (1995)
Human influenza virus recognition of oligosaccharidesFEBS Letters, 366
J. Katz, Xiuhua Lu, T. Tumpey, Catherine Smith, M. Shaw, K. Subbarao (2000)
Molecular Correlates of Influenza A H5N1 Virus Pathogenesis in MiceJournal of Virology, 74
M. Perdue, J. Latimer, J. Crawford (1995)
A novel carbohydrate addition site on the hemagglutinin protein of a highly pathogenic H7 subtype avian influenza virus.Virology, 213 1
V. Hinshaw, C. Olsen, N. Dybdahl-Sissoko, David Evans (1994)
Apoptosis: a mechanism of cell killing by influenza A and B virusesJournal of Virology, 68
S. Baigent, J. McCauley (2001)
Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture.Virus research, 79 1-2
Guangxiang Luo, Chung Jeffrey, P. Palese (1993)
Alterations of the stalk of the influenza virus neuraminidase: deletions and insertions.Virus research, 29 3
J. Bennink, J. Yewdell, G. Smith, B. Moss (1987)
Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a nonstructural protein: responsiveness to individual viral antigens is major histocompatibility complex controlledJournal of Virology, 61
S. Ludwig, Xiuyan Wang, C. Ehrhardt, Hongyong Zheng, Nicola Donelan, O. Planz, S. Pleschka, A. García-Sastre, G. Heins, T. Wolff (2002)
The Influenza A Virus NS1 Protein Inhibits Activation of Jun N-Terminal Kinase and AP-1 Transcription FactorsJournal of Virology, 76
H. Kida, Toshihiro Ito, J. Yasuda, Y. Shimizu, Chitoshi Itakura, K. Shortridge, Y. Kawaoka, R. Webster (1994)
Potential for transmission of avian influenza viruses to pigs.The Journal of general virology, 75 ( Pt 9)
M. Matrosovich, N. Zhou, Y. Kawaoka, R. Webster (1999)
The Surface Glycoproteins of H5 Influenza Viruses Isolated from Humans, Chickens, and Wild Aquatic Birds Have Distinguishable PropertiesJournal of Virology, 73
L. Bazzigher, Annette Schwarz, P. Staeheli (1993)
No enhanced influenza virus resistance of murine and avian cells expressing cloned duck Mx protein.Virology, 195 1
Maria CASTRUCCIt, Y. Kawaoka (1993)
Biologic importance of neuraminidase stalk length in influenza A virusJournal of Virology, 67
K. Okazaki, Y. Kawaoka, R. Webster (1989)
Evolutionary pathways of the PA genes of influenza A viruses.Virology, 172 2
Y. Kawaoka, S. Krauss, R. Webster (1989)
Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemicsJournal of Virology, 63
K. Deshpande, V. Fried, M. Ando, R. Webster (1987)
Glycosylation affects cleavage of an H5N2 influenza virus hemagglutinin and regulates virulence.Proceedings of the National Academy of Sciences of the United States of America, 84 1
A. Stieneke-Grober, M. Vey, Herbert, Angliker, Elliott Shawl, G. Thomas, Christopher Roberts, Hans-Dieter Kienk, W. Garten (1992)
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin‐like endoprotease.The EMBO Journal, 11
The virulence of a virus is determined by its ability to adversely affect the host cell, host organism or population of host organisms. Influenza A viruses have been responsible for four pandemics of severe human respiratory disease this century. Avian species harbour a large reservoir of influenza virus strains, which can contribute genes to potential new pandemic human strains. The fundamental importance of understanding the role of each of these genes in determining virulence in birds and humans was dramatically emphasised by the recent direct transmission of avian influenza A viruses to humans, causing fatal infection but not community spread. An understanding of the factors involved in transmission between avian and mammalian species should assist in the development of better surveillance strategies for early recognition of influenza A virus strains having human pandemic potential, and possibly in the design of anti‐viral strategies. BioEssays 25:657–671, 2003. © 2003 Wiley Periodicals, Inc.
BioEssays – Wiley
Published: Jul 1, 2003
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