Induction of testis‐ova in Japanese medaka ( Oryzias latipes ) exposed to p ‐nonylphenol

Induction of testis‐ova in Japanese medaka ( Oryzias latipes ) exposed to p ‐nonylphenol 4‐Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, a major group of nonionic surfactants. When Japanese medaka, Oryzias latipes were exposed from hatch to 3 months of age to aqueous solutions of NP at nominal concentrations of 10, 50, and 100 μg/L, 50% of the male fish in the 50‐μg/L treatment and 86% of the males in the 100‐μg/L treatment developed testis‐ova, an intersex condition characterized by both testicular and ovarian tissue in the gonad. The ratios of males to females in the control treatment (2:1, M:F) and the 100‐μg/L NP treatment (1:2, M:F) were also significantly different. The LOAEC for induction of testis‐ova at a nominal concentration of 50 μg/L NP is slightly greater than the upper range of concentrations of NP that have been reported in final effluents from municipal sewage treatment plants. Studies on the environmental fate of nonylphenol ethoxylates and degradation products in the aquatic environment are needed to assess the significance of these data in terms of potential reproductive effects in feral fish populations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Environmental Toxicology & Chemistry Wiley

Induction of testis‐ova in Japanese medaka ( Oryzias latipes ) exposed to p ‐nonylphenol

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Publisher
Wiley
Copyright
Copyright © 1997 SETAC
ISSN
0730-7268
eISSN
1552-8618
DOI
10.1002/etc.5620160531
Publisher site
See Article on Publisher Site

Abstract

4‐Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, a major group of nonionic surfactants. When Japanese medaka, Oryzias latipes were exposed from hatch to 3 months of age to aqueous solutions of NP at nominal concentrations of 10, 50, and 100 μg/L, 50% of the male fish in the 50‐μg/L treatment and 86% of the males in the 100‐μg/L treatment developed testis‐ova, an intersex condition characterized by both testicular and ovarian tissue in the gonad. The ratios of males to females in the control treatment (2:1, M:F) and the 100‐μg/L NP treatment (1:2, M:F) were also significantly different. The LOAEC for induction of testis‐ova at a nominal concentration of 50 μg/L NP is slightly greater than the upper range of concentrations of NP that have been reported in final effluents from municipal sewage treatment plants. Studies on the environmental fate of nonylphenol ethoxylates and degradation products in the aquatic environment are needed to assess the significance of these data in terms of potential reproductive effects in feral fish populations.

Journal

Environmental Toxicology & ChemistryWiley

Published: May 1, 1997

References

  • Trace analysis of alkylphenol ethoxylates
    Kubeck, Kubeck; Naylor, Naylor
  • Inhibition of testicular growth in rainbow trout ( Oncorhynchus mykiss ) exposed to estrogenic alkylphenolic chemicals
    Jobling, Jobling; Sheahan, Sheahan; Osborne, Osborne; Matthiessen, Matthiessen; Sumpter, Sumpter
  • Effects of estrogen on gluconeogenesis and related parameters in male rainbow trout
    Washburn, Washburn; Krantz, Krantz; Avery, Avery; Freedland, Freedland

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