Paediatric Anaesthesia, Royal Manchester Children’s Hospital,
Anaesthesia, East Lancashire Hospitals NHS Trust, Blackburn, UK
Paediatric Otorhinolaryngology, Royal Manchester Children’s Hospital,
Paediatric Otolaryngology MAHSC, University of Manchester,
Anaesthesia & Intensive Care Medicine, Manchester Royal Infirmiry,
Central Manchester Foundation Trust, Manchester, UK
Anaesthesia & Intensive Care Medicine, University Hospital South
Manchester, Manchester, UK
University of Manchester, Manchester, UK
NHS England, Manchester, UK
C. Doherty, Royal Manchester Children’s Hospital, Manchester, UK.
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Accepted: 29 September 2017
Incurable, progressive Merkel cell carcinoma: A single-
institution study of 54 cases
Merkel cell carcinoma is an aggressive and fast-growing neuroen-
docrine tumour of the skin. It occurs predominantly on sun-exposed
skin of elderly and/or immunosuppressed people.
Approximately 4% of all patients with Merkel cell carcinoma ini-
tially present with distant metastases, a stage, where palliative treat-
ment is usually considered. Very limited data are available on
palliative treatment in patients suffering from Merkel cell carcinoma.
A multimodal radio/chemotherapy concept is advisable for patients
suffering from an advanced tumour stage or patients who are not
suitable for surgery.
Unfortunately, palliative therapy does not
always translate into a significant survival benefit, in particular the
The purpose of this study was to investigate the clinical outcome
of patients with Merkel cell carcinoma treated at the Medical Univer-
sity of Vienna that suffered from incurable, progressive disease.
MATERIALS AND METHODS
A retrospective medical chart review of all patients with Merkel cell
carcinoma treated at the Medical University of Vienna between
CORRESPONDENCE: OUR EXPERIENCE