Incidence and histologic features of mixed renal tumors

Incidence and histologic features of mixed renal tumors INTRODUCTIONNeoplasms of the kidney and renal collecting system constitute nearly 4% of new cancer diagnoses in the United States each year. Increased detection of renal incidentalomas has paralleled the rapid adoption of cross‐sectional imaging as a diagnostic tool. The vast majority of enhancing, solitary renal masses consist of clear cell, or papillary renal cell carcinoma (RCC), whereas benign lesions are more commonly either angiomyolipoma or renal oncocytoma. The differential diagnosis for a solid renal mass also includes several more uncommon albeit histologically distinct entities.Hybrid renal tumors are classically associated with Birt‐Hogg‐Dubé syndrome or renal oncocytosis, however multiple reports have highlighted sporadic cases in patients without a genetic predisposition. Hybrid renal tumors are specifically those lesions containing elements of chromophobe RCC and renal oncocytoma. While patients with hybrid RCC are recognized to have excellent oncologic outcomes after surgical resection, few studies have investigated the significance of renal tumors that contain other coexistent subtypes.Kidney tumors with two histologic subtypes that are distinctly different from hybrid RCC may be broadly classified as “mixed renal tumors.” Here, we review a large cohort of patients undergoing extirpative surgery for enhancing renal tumors to determine the incidence of mixed histologic features, as well as, association http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Incidence and histologic features of mixed renal tumors

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24879
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONNeoplasms of the kidney and renal collecting system constitute nearly 4% of new cancer diagnoses in the United States each year. Increased detection of renal incidentalomas has paralleled the rapid adoption of cross‐sectional imaging as a diagnostic tool. The vast majority of enhancing, solitary renal masses consist of clear cell, or papillary renal cell carcinoma (RCC), whereas benign lesions are more commonly either angiomyolipoma or renal oncocytoma. The differential diagnosis for a solid renal mass also includes several more uncommon albeit histologically distinct entities.Hybrid renal tumors are classically associated with Birt‐Hogg‐Dubé syndrome or renal oncocytosis, however multiple reports have highlighted sporadic cases in patients without a genetic predisposition. Hybrid renal tumors are specifically those lesions containing elements of chromophobe RCC and renal oncocytoma. While patients with hybrid RCC are recognized to have excellent oncologic outcomes after surgical resection, few studies have investigated the significance of renal tumors that contain other coexistent subtypes.Kidney tumors with two histologic subtypes that are distinctly different from hybrid RCC may be broadly classified as “mixed renal tumors.” Here, we review a large cohort of patients undergoing extirpative surgery for enhancing renal tumors to determine the incidence of mixed histologic features, as well as, association

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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