Inactivation and partition of human T‐cell lymphotrophic virus, type III, during ethanol fractionation of plasma

Inactivation and partition of human T‐cell lymphotrophic virus, type III, during ethanol... Abstract: Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV‐III) by spiking the products of various fractionation stops with HTLV‐III. Tests of inactivation and removal indicated that the ratio of residual live virus in plasma fractions/live virus in starting plasma was about 1 × 10‐15 for precipitate II from which immune globulin for injection is manufactured. The results are reassuring regarding the potential safety of immune globulin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Inactivation and partition of human T‐cell lymphotrophic virus, type III, during ethanol fractionation of plasma

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Abstract

Abstract: Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV‐III) by spiking the products of various fractionation stops with HTLV‐III. Tests of inactivation and removal indicated that the ratio of residual live virus in plasma fractions/live virus in starting plasma was about 1 × 10‐15 for precipitate II from which immune globulin for injection is manufactured. The results are reassuring regarding the potential safety of immune globulin.

Journal

TransfusionWiley

Published: Mar 4, 1986

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