In women with PCOS, waist circumference is a better surrogate of glucose and lipid metabolism than disease status per se

In women with PCOS, waist circumference is a better surrogate of glucose and lipid metabolism... INTRODUCTIONIn addition to its importance in reproductive medicine and gynaecology, polycystic ovary syndrome (PCOS) is recognized to confer an adverse cardiometabolic risk profile and to predispose to Type 2 diabetes and probably cardiovascular disease. For this reason, most guidelines for management of women with PCOS recommend regular screening for dysglycaemia and cardiovascular risk factors.However, it is clear that many women with PCOS, particularly those of normal BMI (body mass index), do not progress to prediabetes or diabetes (9). While there is evidence of increased subclinical atherosclerosis and abnormalities in cardiac morphology and function in women with PCOS, whether this translates into an increased number of cardiovascular events and higher mortality remains contentious. In addition, nonobese women with PCOS have been shown to have normal cardiovascular function. Application of blanket guidelines to all women with PCOS potentially leads to unnecessary anxiety and over‐investigation in these low‐risk women. In contrast, there are many women with ovulatory menstrual cycles and without clinical or biochemical evidence of hyperandrogenism, who are at significant risk of diabetes and cardiovascular disease due to obesity and would benefit from appropriate interventions to recognize and improve risk factors.The use of different diagnostic criteria for PCOS further adds to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Endocrinology Wiley

In women with PCOS, waist circumference is a better surrogate of glucose and lipid metabolism than disease status per se

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0300-0664
eISSN
1365-2265
D.O.I.
10.1111/cen.13542
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONIn addition to its importance in reproductive medicine and gynaecology, polycystic ovary syndrome (PCOS) is recognized to confer an adverse cardiometabolic risk profile and to predispose to Type 2 diabetes and probably cardiovascular disease. For this reason, most guidelines for management of women with PCOS recommend regular screening for dysglycaemia and cardiovascular risk factors.However, it is clear that many women with PCOS, particularly those of normal BMI (body mass index), do not progress to prediabetes or diabetes (9). While there is evidence of increased subclinical atherosclerosis and abnormalities in cardiac morphology and function in women with PCOS, whether this translates into an increased number of cardiovascular events and higher mortality remains contentious. In addition, nonobese women with PCOS have been shown to have normal cardiovascular function. Application of blanket guidelines to all women with PCOS potentially leads to unnecessary anxiety and over‐investigation in these low‐risk women. In contrast, there are many women with ovulatory menstrual cycles and without clinical or biochemical evidence of hyperandrogenism, who are at significant risk of diabetes and cardiovascular disease due to obesity and would benefit from appropriate interventions to recognize and improve risk factors.The use of different diagnostic criteria for PCOS further adds to

Journal

Clinical EndocrinologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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