In vivo effects of the 5‐HT 6 antagonist SB‐271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5‐HT, glutamate and aspartate

In vivo effects of the 5‐HT 6 antagonist SB‐271046 on striatal and frontal cortex... Although the 5‐HT6 receptor subtype was identified some 5 years ago, very little is known about its function within the brain. Here we demonstrate, for the first time, the neurochemical effects of a selective 5‐HT6 receptor ligand. Using in vivo microdialysis in the freely moving rat, we evaluated the effects of the selective 5‐HT6 receptor antagonist SB‐271046 by simultaneous measurement of 5‐hydroxytryptamine (5‐HT), dopamine (DA), noradrenaline (NA), glutamate and aspartate from the striatum and frontal cortex. SB‐271046 did not alter basal levels of 5‐HT, DA and NA in either brain region. Similarly, there was no change basal levels of either of the excitatory amino acids within the striatum. In contrast, administration of SB‐271046 (10 mg kg−1 s.c.) produced a significant (P<0.05), tetrodotoxin‐dependent, increase in extracellular levels of both glutamate and aspartate within the frontal cortex, reaching maximum values of 375.4±82.3 and 215.3±62.1% of preinjection values, respectively. British Journal of Pharmacology (2000) 130, 23–26; doi:10.1038/sj.bjp.0703288 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

In vivo effects of the 5‐HT 6 antagonist SB‐271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5‐HT, glutamate and aspartate

British Journal of Pharmacology, Volume 130 (1) – May 1, 2000

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Publisher
Wiley
Copyright
2000 Nature Publishing Group
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1038/sj.bjp.0703288
pmid
10780993
Publisher site
See Article on Publisher Site

Abstract

Although the 5‐HT6 receptor subtype was identified some 5 years ago, very little is known about its function within the brain. Here we demonstrate, for the first time, the neurochemical effects of a selective 5‐HT6 receptor ligand. Using in vivo microdialysis in the freely moving rat, we evaluated the effects of the selective 5‐HT6 receptor antagonist SB‐271046 by simultaneous measurement of 5‐hydroxytryptamine (5‐HT), dopamine (DA), noradrenaline (NA), glutamate and aspartate from the striatum and frontal cortex. SB‐271046 did not alter basal levels of 5‐HT, DA and NA in either brain region. Similarly, there was no change basal levels of either of the excitatory amino acids within the striatum. In contrast, administration of SB‐271046 (10 mg kg−1 s.c.) produced a significant (P<0.05), tetrodotoxin‐dependent, increase in extracellular levels of both glutamate and aspartate within the frontal cortex, reaching maximum values of 375.4±82.3 and 215.3±62.1% of preinjection values, respectively. British Journal of Pharmacology (2000) 130, 23–26; doi:10.1038/sj.bjp.0703288

Journal

British Journal of PharmacologyWiley

Published: May 1, 2000

References

  • Investigation of stretching behaviour induced by the selective 5‐HT 6 receptor antagonist, Ro 04‐6790, in rats
    BENTLEY, BENTLEY; BOURSON, BOURSON; BOESS, BOESS; FONE, FONE; MARSDEN, MARSDEN; PETIT, PETIT; SLEIGHT, SLEIGHT
  • Involvement of 5‐HT 6 receptors in nigro‐striatal function in rodents
    BOURSON, BOURSON; BOESS, BOESS; BOS, BOS; SLEIGHT, SLEIGHT
  • The cerebral cortex and parafascicular thalamic nucleus facilitate in vivo acetylcholine release in the rat striatum through distinct glutamate receptor subtypes
    CONSOLO, CONSOLO; BALDI, BALDI; GIORGI, GIORGI; NANNINI, NANNINI
  • Effects of 5‐HT 1A receptor antagonists on fluoxetine‐induced changes in serotonin in rat frontal cortex
    DAWSON, DAWSON; NGUYEN, NGUYEN

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