In vitro assessment of the effect of acidemia on coagulation in dogs

In vitro assessment of the effect of acidemia on coagulation in dogs AbbreviationsaPTTactivated partial thromboplastin timeMAmaximum amplitudePTprothrombin timeSAstrong acidemiaTEGthromboelastographyWAweak acidemiaIntroductionCoagulopathies are a frequent finding in patients with trauma. These complex hemostatic disorders are likely multifactorial, as hemostasis may be affected by acid base status, effective circulating volume, body temperature, presence of inflammation, and therapeutic interventions. Acidemia is thought to play a major role in the etiology of coagulopathy of trauma and may lead to increased mortality in human patients. The limited number of studies that evaluate the impact of acidemia on coagulation in people and experimental animals found conflicting results. There is evidence to support that acidemia may contribute to a hypocoagulable state, but some studies could not demonstrate coagulopathy during acidemia, or only found hemostatic abnormalities when acidemia occurred in combination with hypothermia. Two currently published studies of acute traumatic coagulopathy in dogs further add to the confusion. One prospective, observational study reported hypocoagulability in a group of dogs following acute trauma; however, a separate study found that one‐third of patients were hypercoagulable, with no hypocoagulability reported, despite many suffering from acidemia.The objectives of the current study were to investigate the independent effect of acidemia on thromboelastography (TEG) and traditional tests of coagulation in dogs using an in vitro model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Veterinary Emergency and Critical Care Wiley

In vitro assessment of the effect of acidemia on coagulation in dogs

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Veterinary Emergency and Critical Care Society
ISSN
1479-3261
eISSN
1476-4431
D.O.I.
10.1111/vec.12697
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsaPTTactivated partial thromboplastin timeMAmaximum amplitudePTprothrombin timeSAstrong acidemiaTEGthromboelastographyWAweak acidemiaIntroductionCoagulopathies are a frequent finding in patients with trauma. These complex hemostatic disorders are likely multifactorial, as hemostasis may be affected by acid base status, effective circulating volume, body temperature, presence of inflammation, and therapeutic interventions. Acidemia is thought to play a major role in the etiology of coagulopathy of trauma and may lead to increased mortality in human patients. The limited number of studies that evaluate the impact of acidemia on coagulation in people and experimental animals found conflicting results. There is evidence to support that acidemia may contribute to a hypocoagulable state, but some studies could not demonstrate coagulopathy during acidemia, or only found hemostatic abnormalities when acidemia occurred in combination with hypothermia. Two currently published studies of acute traumatic coagulopathy in dogs further add to the confusion. One prospective, observational study reported hypocoagulability in a group of dogs following acute trauma; however, a separate study found that one‐third of patients were hypercoagulable, with no hypocoagulability reported, despite many suffering from acidemia.The objectives of the current study were to investigate the independent effect of acidemia on thromboelastography (TEG) and traditional tests of coagulation in dogs using an in vitro model.

Journal

Journal of Veterinary Emergency and Critical CareWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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