Impulse oscillometry measurement of distal airways obstruction in depleted uranium‐exposed Gulf War veterans

Impulse oscillometry measurement of distal airways obstruction in depleted uranium‐exposed Gulf... INTRODUCTIONDepleted uranium (DU), a man‐made material, possesses the same chemical toxicity as natural uranium (U) metal, but has 40% less radiation, having had much of its higher specific activity isotypes removed. In inhalational models in animals and in humans involved in occupational accidents exposed to U hexafluoride, respiratory system health effects include pulmonary edema, hemorrhage, interstitial inflammation and fibrosis, and emphysema. These effects, however, are thought to be related to hydrogen fluoride toxicity. Uranium miners and millers chronically exposed via inhalation to insoluble U metal compounds also are known to face increased risks of respiratory disease; however, concomitant exposure to silica, diesel exhaust, and cigarette smoke also contribute to this increased risk in this population exposed to U. The clear potential for U‐related respiratory health effects still suggests a need for surveillance, particularly in populations with ongoing exposure.During Gulf War I, the United States military first used DU metal as a munition due to its armor piercing and pyrophoric properties and as armor on U.S. tanks and vehicles due to its high density. A cohort of Gulf War I veterans who sustained exposure to depleted uranium (DU) following friendly fire incidents in 1991 undergoes biennial surveillance supported by the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Industrial Medicine Wiley

Impulse oscillometry measurement of distal airways obstruction in depleted uranium‐exposed Gulf War veterans

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0271-3586
eISSN
1097-0274
D.O.I.
10.1002/ajim.22816
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONDepleted uranium (DU), a man‐made material, possesses the same chemical toxicity as natural uranium (U) metal, but has 40% less radiation, having had much of its higher specific activity isotypes removed. In inhalational models in animals and in humans involved in occupational accidents exposed to U hexafluoride, respiratory system health effects include pulmonary edema, hemorrhage, interstitial inflammation and fibrosis, and emphysema. These effects, however, are thought to be related to hydrogen fluoride toxicity. Uranium miners and millers chronically exposed via inhalation to insoluble U metal compounds also are known to face increased risks of respiratory disease; however, concomitant exposure to silica, diesel exhaust, and cigarette smoke also contribute to this increased risk in this population exposed to U. The clear potential for U‐related respiratory health effects still suggests a need for surveillance, particularly in populations with ongoing exposure.During Gulf War I, the United States military first used DU metal as a munition due to its armor piercing and pyrophoric properties and as armor on U.S. tanks and vehicles due to its high density. A cohort of Gulf War I veterans who sustained exposure to depleted uranium (DU) following friendly fire incidents in 1991 undergoes biennial surveillance supported by the

Journal

American Journal of Industrial MedicineWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ;

References

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