Implementing a unified approach to family‐based tests of association

Implementing a unified approach to family‐based tests of association We describe a broad class of family‐based association tests that are adjusted for admixture; use either dichotomous or measured phenotypes; accommodate phenotype‐unknown subjects; use nuclear families, sibships or a combination of the two, permit multiple nuclear families from a single pedigree; incorporate di‐ or multi‐allelic marker data; allow additive, dominant or recessive models; and permit adjustment for covariates and gene‐by‐environment interactions. The test statistic is the covariance between a user‐specified function of the genotype and a user‐specified function of the trait. The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture. Genet. Epidemiol. 19(Suppl 1):S36–S42, 2000. © 2000 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetic Epidemiology Wiley

Implementing a unified approach to family‐based tests of association

Genetic Epidemiology, Volume 19 (S1) – Jan 1, 2000

Loading next page...
 
/lp/wiley/implementing-a-unified-approach-to-family-based-tests-of-association-55fIT0qCFB
Publisher
Wiley
Copyright
Copyright © 2000 Wiley‐Liss, Inc.
ISSN
0741-0395
eISSN
1098-2272
D.O.I.
10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.3.CO;2-D
Publisher site
See Article on Publisher Site

Abstract

We describe a broad class of family‐based association tests that are adjusted for admixture; use either dichotomous or measured phenotypes; accommodate phenotype‐unknown subjects; use nuclear families, sibships or a combination of the two, permit multiple nuclear families from a single pedigree; incorporate di‐ or multi‐allelic marker data; allow additive, dominant or recessive models; and permit adjustment for covariates and gene‐by‐environment interactions. The test statistic is the covariance between a user‐specified function of the genotype and a user‐specified function of the trait. The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture. Genet. Epidemiol. 19(Suppl 1):S36–S42, 2000. © 2000 Wiley‐Liss, Inc.

Journal

Genetic EpidemiologyWiley

Published: Jan 1, 2000

Keywords: tests of association; family based controls; transmission disequilibrium tests

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off