Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats 1 Diabetes mellitus is known to produce alterations in vascular reactivity. The present study examined the effects of endothelium‐dependent and endothelium‐independent relaxing substances on thoracic aorta from control and spontaneously diabetic rats. 2 Endothelium‐dependent relaxation produced by acetylcholine or the calcium ionophore, A23817, in aortic rings precontracted with phenylephrine was significantly attenuated in diabetic vessels. 3 Relaxations produced by sodium nitroprusside or adenosine in diabetic preparations were comparable to those in control vessels. 4 The results show that diabetes leads to a specific impairment of endothelial‐dependent relaxation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

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Abstract

1 Diabetes mellitus is known to produce alterations in vascular reactivity. The present study examined the effects of endothelium‐dependent and endothelium‐independent relaxing substances on thoracic aorta from control and spontaneously diabetic rats. 2 Endothelium‐dependent relaxation produced by acetylcholine or the calcium ionophore, A23817, in aortic rings precontracted with phenylephrine was significantly attenuated in diabetic vessels. 3 Relaxations produced by sodium nitroprusside or adenosine in diabetic preparations were comparable to those in control vessels. 4 The results show that diabetes leads to a specific impairment of endothelial‐dependent relaxation.

Journal

British Journal of PharmacologyWiley

Published: Jun 1, 1988

References

  • Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries
    DeMEY, DeMEY; VANHOUTTE, VANHOUTTE
  • Role of endothelium in responses of vascular smooth muscle
    FURCHGOTT, FURCHGOTT
  • Insulin reversal of diabetes‐induced inhibition of vascular contractility in the rat
    PFAFFMAN, PFAFFMAN; BALL, BALL; DARBY, DARBY; HILMAN, HILMAN
  • Diminished contractile response of aortas of diabetic rabbits
    SULLIVAN, SULLIVAN; SPARKS, SPARKS

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