INTRODUCTIONAortic stenosis (AS) remains the most common valvular heart disease of older adults, affecting over 3% of the elderly population . Surgical aortic valve replacement (SAVR) has long been the standard of care for symptomatic AS yet 30–40% of patients are deemed too high risk for surgical intervention . Since the PARTNER trial, transcatheter aortic valve replacement (TAVR) has emerged as an alternative to SAVR in patients considered inoperable or too high risk due to advanced age and comorbidities . More recently, the PARTNER II trial demonstrated comparable efficacy in intermediate risk patients (STS score < 8) . Studies from the PARTNER trial have also shown that aortic annulus size had a major impact on valve hemodynamics and clinical outcomes after TAVR and SAVR with larger annuli in TAVR associated with a greater incidence of moderate/severe paravalvular regurgitation but lower rates of severe prosthesis‐patient mismatch (PPM) .PPM, an inadequately sized effective orifice area of an implanted prosthesis relative to patient body size, can result in high transprosthesis gradients, resulting in greater left ventricular effort, a subsequent reduction in left ventricular mass regression, and ultimately reduced survival . SAVR in patients with severe AS who have small aortic annuli has been associated
Catheterization and Cardiovascular Interventions – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud