Impact of diabetes mellitus and hepatitis B virus coinfection on patients with chronic hepatitis C: A territory‐wide cohort study

Impact of diabetes mellitus and hepatitis B virus coinfection on patients with chronic hepatitis... IntroductionGlobally, around 71 million people are chronic hepatitis C (CHC) patients. These infections often become chronic, progressing to cirrhosis, end‐stage liver disease, and hepatocellular carcinoma (HCC). CHC is one of the leading causes of liver transplantation.Chronic hepatitis C patients have been shown to have a higher prevalence of type 2 diabetes mellitus (DM). However, the exact association between the two diseases is not fully understood. This is particularly true in Asians as studies on these populations are scarce. The liver is important for preserving glucose homeostasis, which would be disturbed in liver disorders.Another special feature in Asia–Pacific and some European regions would be coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV), as both infections can be prevalent at the same time in some of these regions. Studies from Spain, Italy, Japan, Taiwan, and Iran reveal that 2% to 25% of CHC patients are also positive for hepatitis B surface antigen (HBsAg). There is well‐established virologic evidence of viral interference in HBV/HCV coinfected patients, yet there are still many gaps in the understanding of the interaction between the two viruses in terms of natural history and response to antiviral treatments.Such a high prevalence of DM and chronic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Gastroenterology and Hepatology Wiley

Impact of diabetes mellitus and hepatitis B virus coinfection on patients with chronic hepatitis C: A territory‐wide cohort study

Loading next page...
 
/lp/wiley/impact-of-diabetes-mellitus-and-hepatitis-b-virus-coinfection-on-SMosmYBNyt
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
ISSN
0815-9319
eISSN
1440-1746
D.O.I.
10.1111/jgh.14003
Publisher site
See Article on Publisher Site

Abstract

IntroductionGlobally, around 71 million people are chronic hepatitis C (CHC) patients. These infections often become chronic, progressing to cirrhosis, end‐stage liver disease, and hepatocellular carcinoma (HCC). CHC is one of the leading causes of liver transplantation.Chronic hepatitis C patients have been shown to have a higher prevalence of type 2 diabetes mellitus (DM). However, the exact association between the two diseases is not fully understood. This is particularly true in Asians as studies on these populations are scarce. The liver is important for preserving glucose homeostasis, which would be disturbed in liver disorders.Another special feature in Asia–Pacific and some European regions would be coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV), as both infections can be prevalent at the same time in some of these regions. Studies from Spain, Italy, Japan, Taiwan, and Iran reveal that 2% to 25% of CHC patients are also positive for hepatitis B surface antigen (HBsAg). There is well‐established virologic evidence of viral interference in HBV/HCV coinfected patients, yet there are still many gaps in the understanding of the interaction between the two viruses in terms of natural history and response to antiviral treatments.Such a high prevalence of DM and chronic

Journal

Journal of Gastroenterology and HepatologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off