Impact of diabetes mellitus and hepatitis B virus coinfection on patients with chronic hepatitis C: A territory‐wide cohort study

Impact of diabetes mellitus and hepatitis B virus coinfection on patients with chronic hepatitis... IntroductionGlobally, around 71 million people are chronic hepatitis C (CHC) patients. These infections often become chronic, progressing to cirrhosis, end‐stage liver disease, and hepatocellular carcinoma (HCC). CHC is one of the leading causes of liver transplantation.Chronic hepatitis C patients have been shown to have a higher prevalence of type 2 diabetes mellitus (DM). However, the exact association between the two diseases is not fully understood. This is particularly true in Asians as studies on these populations are scarce. The liver is important for preserving glucose homeostasis, which would be disturbed in liver disorders.Another special feature in Asia–Pacific and some European regions would be coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV), as both infections can be prevalent at the same time in some of these regions. Studies from Spain, Italy, Japan, Taiwan, and Iran reveal that 2% to 25% of CHC patients are also positive for hepatitis B surface antigen (HBsAg). There is well‐established virologic evidence of viral interference in HBV/HCV coinfected patients, yet there are still many gaps in the understanding of the interaction between the two viruses in terms of natural history and response to antiviral treatments.Such a high prevalence of DM and chronic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Gastroenterology and Hepatology Wiley

Impact of diabetes mellitus and hepatitis B virus coinfection on patients with chronic hepatitis C: A territory‐wide cohort study

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
ISSN
0815-9319
eISSN
1440-1746
D.O.I.
10.1111/jgh.14003
Publisher site
See Article on Publisher Site

Abstract

IntroductionGlobally, around 71 million people are chronic hepatitis C (CHC) patients. These infections often become chronic, progressing to cirrhosis, end‐stage liver disease, and hepatocellular carcinoma (HCC). CHC is one of the leading causes of liver transplantation.Chronic hepatitis C patients have been shown to have a higher prevalence of type 2 diabetes mellitus (DM). However, the exact association between the two diseases is not fully understood. This is particularly true in Asians as studies on these populations are scarce. The liver is important for preserving glucose homeostasis, which would be disturbed in liver disorders.Another special feature in Asia–Pacific and some European regions would be coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV), as both infections can be prevalent at the same time in some of these regions. Studies from Spain, Italy, Japan, Taiwan, and Iran reveal that 2% to 25% of CHC patients are also positive for hepatitis B surface antigen (HBsAg). There is well‐established virologic evidence of viral interference in HBV/HCV coinfected patients, yet there are still many gaps in the understanding of the interaction between the two viruses in terms of natural history and response to antiviral treatments.Such a high prevalence of DM and chronic

Journal

Journal of Gastroenterology and HepatologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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