IntroductionBifidobacterium is commonly used as a probiotic, being added to fermented food and formula powder. However, some genera of Bifidobacterium exhibit weak resistance to stress and this limits their probiotic function and restricts their application in the food industry (Champagne et al. ; O'May et al. ). Previous studies have indicated that AI‐2 also plays a crucial role in gut colonization and the probiotic functionality of Bifidobacterium (Christiaen et al. ), and inducing the pre‐acid tolerance response (ATR) in such genera could strengthen their acid resistance to subsequent pH stress (Maus and Ingham ; Jin et al. , ). The LuxS/AI‐2 quorum‐sensing system participates in the ATR in Bifidobacterium (Han et al. ). Hence, regulating AI‐2 secretion may be a promising strategy to improve the tolerance of Bifidobacterium.LuxS/AI‐2 quorum sensing is a process of bacterial cell–cell communication that uses small diffusible molecules to coordinate diverse behaviours in response to variable environments (Keersmaecker et al. ). Previous studies have reported that the growth phase affects AI‐2 activity in Lactobacillus (Hardie et al. ; Moslehi‐Jenabian et al. ); the type of unique carbon source has also been shown to affect the secretion of AI‐2 in several pathogenic strains (Hardie et al. ; Han and Lu ; Han et al. ; Yang et al.
Letters in Applied Microbiology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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