Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies

Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple... 1 A role of the immune system in muscular adaptation to physical exercise has been suggested but data from controlled human studies are scarce. The present study investigated immunological events in human blood and skeletal muscle by immunohistochemistry and flow cytometry after eccentric cycling exercise and multiple biopsies. 2 Immunohistochemical detection of neutrophil‐ (CD11b, CD15), macrophage‐ (CD163), satellite cell‐ (CD56) and IL‐1β‐specific antigens increased similarly in human skeletal muscle after eccentric cycling exercise together with multiple muscle biopsies, or multiple biopsies only. 3 Changes in immunological variables in blood and muscle were related, and monocytes and natural killer (NK) cells appeared to have governing functions over immunological events in human skeletal muscle. 4 Delayed onset muscle soreness, serum creatine kinase activity and C‐reactive protein concentration were not related to leukocyte infiltration in human skeletal muscle. 5 Eccentric cycling and/or muscle biopsies did not result in T cell infiltration in human skeletal muscle. Modes of stress other than eccentric cycling should therefore be evaluated as a myositis model in human. 6 Based on results from the present study, and in the light of previously published data, it appears plausible that muscular adaptation to physical exercise occurs without preceding muscle inflammation. Nevertheless, leukocytes seem important for repair, regeneration and adaptation of human skeletal muscle. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies

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Publisher
Wiley
Copyright
Copyright © 2000 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1111/j.1469-7793.2000.00243.x
Publisher site
See Article on Publisher Site

Abstract

1 A role of the immune system in muscular adaptation to physical exercise has been suggested but data from controlled human studies are scarce. The present study investigated immunological events in human blood and skeletal muscle by immunohistochemistry and flow cytometry after eccentric cycling exercise and multiple biopsies. 2 Immunohistochemical detection of neutrophil‐ (CD11b, CD15), macrophage‐ (CD163), satellite cell‐ (CD56) and IL‐1β‐specific antigens increased similarly in human skeletal muscle after eccentric cycling exercise together with multiple muscle biopsies, or multiple biopsies only. 3 Changes in immunological variables in blood and muscle were related, and monocytes and natural killer (NK) cells appeared to have governing functions over immunological events in human skeletal muscle. 4 Delayed onset muscle soreness, serum creatine kinase activity and C‐reactive protein concentration were not related to leukocyte infiltration in human skeletal muscle. 5 Eccentric cycling and/or muscle biopsies did not result in T cell infiltration in human skeletal muscle. Modes of stress other than eccentric cycling should therefore be evaluated as a myositis model in human. 6 Based on results from the present study, and in the light of previously published data, it appears plausible that muscular adaptation to physical exercise occurs without preceding muscle inflammation. Nevertheless, leukocytes seem important for repair, regeneration and adaptation of human skeletal muscle.

Journal

The Journal of PhysiologyWiley

Published: Nov 1, 2000

References

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